2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate CAS:86520-63-0

I-2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate yikhemikhali yekhemikhali esetyenziswa ngokuqhelekileyo kwi-carbohydrate chemistry kunye ne-glycosylation reactions.Iphuma kwi-α-D-galactopyranose, uhlobo lweswekile, apho amaqela e-hydroxyl kwi-2, 3, 4, kunye ne-6 isikhundla sendandatho ye-galactopyranose i-acetylated.Ukongezelela, i-anomeric carbon (C1) yeswekile ikhuselwe kunye neqela le-trichloroacetimidate, elenza i-electrophile enamandla ngexesha lokuphendula kwe-glycosylation.

Ikhompawundi isoloko isetyenziswa njenge-agent ye-glycosylating ukwazisa i-galactose moieties kwiimolekyuli ezahlukeneyo, ezifana neeprotheni, iipeptides, okanye iimolekyuli ezincinci zezinto eziphilayo.Oku kunokufezekiswa ngokuphendula le ngqungquthela kunye ne-nucleophile (umzekelo, amaqela e-hydroxyl kwi-molecule ekujoliswe kuyo) phantsi kweemeko ezifanelekileyo.Iqela le-trichloroacetimidate liququzelela ukudibanisa kwe-galactose moiety kwi-molecule ejoliswe kuyo, okubangelwa ukubunjwa kwebhondi ye-glycosidic.

Le khompawundi isetyenziswa ngokuqhelekileyo kwi-synthesis ye-glycoconjugates, i-glycopeptides, kunye ne-glycolipids.Inika indlela eguquguqukayo nesebenzayo yokuguqula iimolekyuli ezineentsalela zegalactose, ezinokuthi zifaneleke kwiinkalo ezahlukeneyo, kubandakanywa izifundo zebhayoloji, iinkqubo zokuhanjiswa kweziyobisi, okanye uphuhliso lwesitofu sokugonya.

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I-Glycosylation: Ikhompawundi iphendula ngeeathom ezahlukeneyo zokwamkela eziqulathe amaqela e-hydroxyl, afana neealkoholi okanye ii-amines, ukwenza iibhondi ze-glycosidic.Oku kuvumela ukuqaliswa kwe-galactose kwi-molecule eyamkelekileyo, okubangelwa ukuhlanganiswa kwe-glyccoconjugates, i-glycopeptides, okanye i-glycolipids.

Izifundo zebhayoloji kunye nebhayoloji: Ikhompawundi inceda abaphandi bafunde imisebenzi yebhayoloji kunye nokunxibelelana kweemolekyuli ezinegalactose.Ngokukhetha ngokukhetha i-galactose kwiiprotheni, i-peptides, okanye ezinye ii-biomolecules, abaphandi banokuphanda indima yabo kwiinkqubo zeselula, ukusebenzisana kwe-receptor-ligand, kunye neendlela zokugula.

Iinkqubo zokuhanjiswa kweziyobisi: Ikhompawundi ingasetyenziselwa ukuguqula iimolekyuli zamachiza kunye neentsalela ze-galactose, ukuququzelela ukuhanjiswa kweziyobisi ezijoliswe kuzo kwiizicubu okanye iiseli ezithile.I-Galactose inokusebenza njenge-ligand ejoliswe kuyo, iqonda i-receptors ethile echazwe kumphezulu weeseli, ngakumbi i-hepatocytes.Ngokufakela i-galactose kumachiza, abaphandi banokuphucula ukukhethwa kwabo kunye nokusebenza kakuhle kunyango olujoliswe kuyo.

Ukuphuhliswa kogonyo: Iimolekyuli ezine-galactose zidlala indima ebalulekileyo kwiimpendulo ze-immune, njengoko zibonwa ngama-lectins akhoyo kwiiseli zomzimba.Ngokudibanisa ii-antigens kunye ne-galactose moieties usebenzisa le khompawundi, abaphandi banokuphucula iimpendulo zokuzivikela komzimba kwaye baphuhlise izitofu ezisebenzayo ngakumbi.

I-Chemical synthesis: Ikhompawundi ingasetyenziswa kwiintlobo ezahlukeneyo zemichiza apho kufuneka uhlengahlengiso lwegalactose.Oku kubandakanya ukulungiswa kwezakhiwo ze-carbohydrate eziyinkimbinkimbi, i-oligosaccharides, okanye i-glycomimetics, enokuthi isetyenziswe ngakumbi kwi-chemistry yamayeza okanye njengezixhobo zophando.

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Iinkcukacha ezongezelelweyo:

Ukuqamba	I-C16H20Cl3NO10
Isivavanyi	99%
Imbonakalo	Umgubo omhlophe
Inombolo yeCAS.	86520-63-0
Ukupakisha	Incinci kwaye ininzi
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.