2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate CAS:86520-63-0

I-2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate yikhemikhali esetyenziswa kakhulu kwi-carbohydrate chemistry kunye neempendulo ze-glycosylation. Yinto evela kwi-α-D-galactopyranose, uhlobo lweswekile, apho amaqela e-hydroxyl kwizikhundla ze-2, 3, 4, kunye ne-6 ze-galactopyranose ring afakwe i-acetylated. Ukongeza, i-anomeric carbon (C1) yeswekile ikhuselwe liqela le-trichloroacetimidate, elenza libe yi-electrophile enamandla ngexesha leempendulo ze-glycosylation.

Le compound idla ngokusetyenziswa njenge-glycosylating agent ukufaka ii-galactose moieties kwiimolekyuli ezahlukeneyo, ezifana neeproteni, iipeptides, okanye iimolekyuli ezincinci ze-organic. Oku kunokufezekiswa ngokusabela le compound nge-nucleophile (umz., amaqela e-hydroxyl kwimolekyuli ekujoliswe kuyo) phantsi kweemeko ezifanelekileyo. Iqela le-trichloroacetimidate lenza kube lula ukunamatheliswa kwe-galactose moiety kwimolekyuli ekujoliswe kuyo, nto leyo ekhokelela ekwakhekeni kwe-glycosidic bond.

Le khompawundi isetyenziswa kakhulu ekuhlanganiseni ii-glycoconjugates, ii-glycopeptides, kunye nee-glycolipids. Ibonelela ngendlela eguquguqukayo nesebenzayo yokuguqula iimolekyuli ezinee-galactose residues, ezinokuba luncedo kwiinkalo ezahlukeneyo, kubandakanya izifundo zebhayoloji, iinkqubo zokuhambisa amayeza, okanye uphuhliso lwe-vaccine.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

I-Glycosylation: Le compound isabela kwiimolekyuli ezahlukeneyo ze-acceptor eziqulathe amaqela e-hydroxyl, njengee-alcohols okanye ii-amines, ukuze zenze ii-glycosidic bonds. Oku kuvumela ukungena kwe-galactose kwi-acceptor molecule, nto leyo ekhokelela ekuhlanganisweni kwee-glycoconjugates, ii-glycopeptides, okanye ii-glycolipids.

Izifundo zebhayoloji nezebhayoloji: Le khompawundi inceda abaphandi ukuba bafunde imisebenzi yebhayoloji kunye nokusebenzisana kweemolekyuli ezinegalactose. Ngokuncamathisela igalactose kwiiproteni, iipeptides, okanye ezinye iimolekyuli, abaphandi banokuphanda iindima zabo kwiinkqubo zeseli, ukusebenzisana kwe-receptor-ligand, kunye neendlela zesifo.

Iinkqubo zokuhambisa amayeza: Le compound ingasetyenziselwa ukuguqula iimolekyuli zamayeza kunye neentsalela zegalactose, iququzelele ukuhanjiswa kwamayeza athile kwiithishu okanye kwiiseli ezithile. IGalactose ingasebenza njenge-ligand ekujoliswe kuyo, iqaphela ii-receptors ezithile ezivezwa kumphezulu weeseli, ngakumbi ii-hepatocytes. Ngokuncamathisela i-galactose kumayeza, abaphandi banokuphucula ukukhetha kwabo kunye nokusebenza kakuhle kunyango olujoliswe kulo.

Uphuhliso lwegonyo: Iimolekyuli ezineGalactose zidlala indima ebalulekileyo kwiimpendulo zomzimba, njengoko ziqatshelwa zii-lectins ezikhoyo kwiiseli zomzimba. Ngokudibanisa ii-antigens kunye nee-galactose groupies besebenzisa le khompawundi, abaphandi banokuphucula iimpendulo zomzimba zomzimba kwaye baphuhlise iigonyo ezisebenzayo ngakumbi.

Ukwenziwa kweekhemikhali: Le compound ingasetyenziswa kwiindidi ezahlukeneyo zeekhemikhali apho kufuneka utshintsho lwegalactose. Oku kuquka ukulungiswa kwezakhiwo zecarbohydrate ezintsonkothileyo, ii-oligosaccharides, okanye ii-glycomimetics, ezingasetyenziswa ngakumbi kwikhemistri yezonyango okanye njengezixhobo zophando.

Isampuli yeMveliso

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	C16H20Cl3NO10
Uvavanyo	99%
Inkangeleko	Umgubo omhlophe
Inombolo ye-CAS	86520-63-0
Ukupakisha	Encinci kwaye ininzi
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.