Mirabegron CAS:223673-61-8 uMboneleli woMvelisi oMfanisiweyo

I-Mirabegron CAS: 223673-61-8 uMboneleli woMvelisi

I-Mirabegron yeyonyango longxamiseko, ukuphindaphinda komchamo, kunye ne-urinary urgence incontinence yomchamo ehambelana ne-bladder esebenzayo (OAB).I-Mirabegron yenziwe ngokudibanisa i-4-nitrophenethyl amine ukuya (R) -2-hydroxy-2-phenylacetic acid.I-amide yesiphumo iyancitshiswa ibe yi-amine.Iqela le-nitro liyancitshiswa kwaye isiphumo sidityaniswa kwi-2-(2-aminothiazol-4-yl) i-acetic acid ukunika i-mirabegron.

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I-Mirabegron yi-agonist esebenzayo yomlomo we-β3-adrenoceptor okwangoku ekuphuhlisweni ngu-Astellas Pharma kunyango lwe-bladder esebenzayo (OAB).Ichiza liyi-nanomolar EC50 inchasi ngokuchasene ne-β3-AR ye-biochemical assays kunye nokukhetha okulungileyo kwi-b1- kunye ne-β2-ARs.I-Mirabegron ibonisa indlela yenoveli ngokujolisa kwi-β3-AR yokuphumla kwe-bladder ukunceda ukulawula iimpawu ze-OAB ezifana nokunyuka kokunyuka komchamo kunye nokuphindaphinda kunye nokungahambi ngokukhawuleza.Nangona kunjalo, i-mirabegron yi-cytochrome P450 2D6 inhibitor, kwaye iphakamisa inkxalabo yokusebenzisana neziyobisi kunye nolawulo oluhambelanayo lwezinye i-cytochrome P450 2D6 substrates.

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Iinkcukacha ezongezelelweyo:

Ukuqamba	I-C21H24N4O2S
Isivavanyi	99%
Imbonakalo	Umgubo oMhlophe ukuya koMthubi
Inombolo yeCAS.	223673-61-8
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.