I-Mirabegron CAS:223673-61-8 Umthengisi woMvelisi Umfanekiso oPhambili

Umthengisi weMirabegron CAS:223673-61-8

IMirabegron yeyonyango lokungxamiseka, ukuphindaphindeka komchamo, kunye nokungakwazi ukuzibamba komchamo okunxulunyaniswa ne-overactive bladder (OAB). IMirabegron yenziwa ngokuhlanganisa i-4-nitrophenethyl amine kwi-(R)-2-hydroxy-2-phenylacetic acid. I-amide ephumayo iyancitshiswa ibe yi-amine. Iqela le-nitro liyancitshiswa kwaye okuphumayo kudityaniswa ne-2-(2-aminothiazol-4-yl) acetic acid ukunika i-mirabegron.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

I-Mirabegron yi-agonist esebenzayo ngomlomo ye-β3-adrenoceptor okwangoku ephuhliswa yi-Astellas Pharma yokunyanga isinyi esisebenza kakhulu (OAB). Eli yeza lichasene ne-nanomolar EC50 ngokuchasene novavanyo lwe-β3-AR lwe-human biochemical olunokukhetha okuhle ngaphezu kwe-b1- kunye ne-β2-ARs. I-Mirabegron ibonisa indlela entsha ngokujolisa i-β3-AR yokuphumla kwesinyi ukunceda ukulawula iimpawu ze-OAB ezifana nokunyuka kongxamiseko lomchamo kunye nokuphindaphindeka kunye nokungakwazi ukuzibamba ngokukhawuleza. Nangona kunjalo, i-mirabegron yi-cytochrome P450 2D6 inhibitor, kwaye iphakamisa inkxalabo yokusebenzisana kwamayeza kunye neziyobisi kunye nokuphathwa ngaxeshanye kwezinye ii-substrates ze-cytochrome P450 2D6.

Isampuli yeMveliso

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	C21H24N4O2S
Uvavanyo	99%
Inkangeleko	Umgubo omhlophe ukuya kophuzi otyheli
Inombolo ye-CAS	223673-61-8
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.