I-Hydrocortisone, i-11β, 17,21-trihydroxypregn-4-ene-3,20-dione, yi-GCin yendalo ephambili yabantu.Ngaphandle kwenani elikhulu lee-GC zokwenziwa, i-hydrocortisone, ii-esters zayo, kunye neetyuwa zayo zihlala ziyintsika yonyango lwangoku lwe-adrenocortical steroid kunye nomgangatho wokuthelekisa zonke ezinye ii-GC kunye nee-MCs.Isetyenziselwa zonke izibonakaliso ezikhankanywe ngaphambili.