Tofacitinib CAS:477600-75-2 uMboneleli woMvelisi

I-Tofacitinib yi-molecule yokuqala encinci ye-kinase inhibitor evunyiweyo kunyango lwe-RA.I-Tofacitinib iyi-inhibitor ye-subtypes ezine ze-Janus kinase (JAK): i-JAK1, i-JAK2, i-JAK3, kunye ne-Tyk2.Izenzo ze-Tofacitinib ngokuvimbela i-phosphorylation kunye nokusebenza kwe-transducers yesignali kunye ne-activators of transcription (STATs), ngaloo ndlela icinezela abalamli abavuthayo. kwizicubu ezidibeneyo.

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Iinkcukacha zeMveliso

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Isicelo kunye nesiphumo

I-Tofacitinib lichiza lokunyanga i-rheumatoid arthritis (RA), i-psoriasis, isifo sokukrala kwamathumbu, kunye nezinye izifo ze-immunological, kunye nokuthintela ukulahlwa kwe-organ transplant.Kuyi-inhibitor ye-enzyme i-Janus kinase 3 (JAK3), oku kuthetha ukuba iphazamisa indlela yokubonisa i-JAK-STAT ehambisa ulwazi ngaphandle kweseli kwi-nucleus yeseli, echaphazela ukubhaliswa kwe-DNA.Kungekudala kuboniswe kumzekelo we-murine we-arthritis esungulwe, i-tofacitinib iphuculwe ngokukhawuleza isifo ngokuvimbela ukuveliswa kwabalamli abavuthayo kunye nokucinezela i-STAT1-exhomekeke kwi-STAT1 kwizicubu ezidibeneyo. Indlela, ecebisa ukuba i-tofacitinib inokusebenzisa isibonelelo sonyango ngeendlela ezingaphelelanga ekuthinteleni i-JAK3.

Isampulu yeMveliso

Ukupakishwa kweMveliso:

Iinkcukacha ezongezelelweyo:

Ukuqamba	I-C16H20N6O
Isivavanyi	99%
Imbonakalo	Umgubo omhlophe ngaphandle
Inombolo yeCAS.	477600-75-2
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.