I-Tofacitinib CAS:477600-75-2 Umthengisi woMvelisi Umfanekiso oPhambili

Umthengisi weTofacitinib CAS:477600-75-2

I-Tofacitinib yi-molecule kinase inhibitor yokuqala encinci evunyiweyo yonyango lwe-RA. I-Tofacitinib yi-inhibitor yeentlobo ezine zeJanus kinase (JAK): i-JAK1, i-JAK2, i-JAK3, kunye ne-Tyk2. I-Tofacitinib isebenza ngokuthintela i-phosphorylation kunye nokusebenza kwe-signal transducers kunye ne-activators of transcription (STATS), ngaloo ndlela icinezela ukuveliswa kwe-inflammatory mediators kwizicubu ezidibeneyo.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

I-Tofacitinib liyeza lokunyanga isifo samathambo esibizwa ngokuba yi-rheumatoid arthritis (RA), i-psoriasis, isifo samathumbu esidumbileyo, kunye nezinye izifo ze-immunological, kunye nokuthintela ukwaliwa kokufakelwa kwamalungu omzimba. Ingumthinteli we-enzyme iJanus kinase 3 (JAK3), oko kuthetha ukuba iphazamisa indlela yokubonisa ye-JAK-STAT edlulisela ulwazi ngaphandle kweseli kwi-nucleus yeseli, ichaphazela ukubhalwa kwe-DNA. Kutshanje iboniswe kwimodeli ye-murine ye-arthritis esekwe, i-tofacitinib iphucula ngokukhawuleza isifo ngokuthintela ukuveliswa kwezinto ezibangela ukudumba kunye nokuthintela ii-genes ezixhomekeke kwi-STAT1 kwizicubu ezidibeneyo. Oku kusebenza kakuhle kule modeli yesifo kunxulumene nokuthintela zombini iindlela zokubonisa ze-JAK1 kunye ne-3, nto leyo ebonisa ukuba i-tofacitinib inokuba luncedo kunyango ngeendlela ezingezizo zokuthintela i-JAK3 kuphela.

Isampuli yeMveliso

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	C16H20N6O
Uvavanyo	99%
Inkangeleko	Umgubo omhlophe ongacacanga
Inombolo ye-CAS	477600-75-2
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.