I-β-Nicotinamide Adenine Dinucleotide CAS:53-84-9

I-NAD+ ibaluleke kakhulu ekusebenzeni kweseli kwaye ifumene umdla kwiindawo ezifana nophando lokwaluphala, imetabolism, kunye nempilo yeseli. Njenge-coenzyme, i-NAD+ ibandakanyeka kwiimpendulo ze-redox ezibalulekileyo kwimveliso yamandla ngaphakathi kwe-mitochondria, ixhasa iinkqubo ezifana ne-glycolysis, umjikelo we-tricarboxylic acid, kunye ne-oxidative phosphorylation. Ukongeza, i-NAD+ isebenza njengesiseko see-enzymes ezifana ne-sirtuins kunye ne-PARPs, ezibandakanyeka ekulungisweni kwe-DNA, ukulawulwa kokubonakaliswa kwezakhi zofuzo, kunye neendlela zokuphendula uxinzelelo lweseli. Kwiminyaka yakutshanje, ii-precursors ze-NAD+, ezifana ne-nicotinamide riboside (NR) kunye ne-nicotinamide mononucleotide (NMN), zifumene ingqalelo njengezongezo ezinokubakho zokuxhasa amanqanaba e-NAD+ ngaphakathi kweeseli. Uphando lubonisa ukuba ukugcina amanqanaba e-NAD+ afanelekileyo kunokudlala indima kwi-biogenesis ye-mitochondrial, i-homeostasis yemetabolism, kunye nokuphila ixesha elide. Ngenxa yoko, ii-precursors ze-NAD+ ziyaphandwa malunga namandla azo okunciphisa ukwehla okunxulumene nobudala, ukuxhasa ukwaluphala okunempilo, kunye nokujongana nokungalingani kwemetabolism okunxulunyaniswa neemeko ezifana nokutyeba kakhulu kunye nesifo seswekile. Ngaphezu koko, i-NAD+ yindawo enomdla okhulayo kwi-physiology yezemidlalo kunye nokuzilolonga ngenxa yokubandakanyeka kwayo kwi-metabolism yamandla kunye nomsebenzi we-mitochondrial. Izifundo ezihlola ukuguqulwa kwe-NAD+ ngokunxulumene nokusebenza komthambo, ukubuyiselwa kwemisipha, kunye namandla okunyamezela ziyaqhubeka, kunye nefuthe elinokubakho ekusebenzeni kwezemidlalo kunye nokuqina komzimba. Ngokubanzi, i-NAD+ kunye nezinto ezandulelayo zimele indawo esebenzayo yophando lwesayensi kunye nezicelo ezinokubakho eziquka ukwaluphala, impilo yeselula, imetabolism, kunye ne-physiology yokuzilolonga, ebonisa indawo ebanzi neguqukayo yophando kunye nokubaluleka okunokwenzeka konyango.