I-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID CAS:113100-53-1

I-1-Methyl-3- (trifluoromethyl)-1H-pyrazole-4-carboxylic acid yenziwa ngeendlela zeekhemikhali eziphilayo, ezibandakanya iimpendulo ezizisa ii-athomu ze-fluorine kunye neqela le-methyl kwisiseko se-pyrazole. Imolekyuli ephumayo ineempawu ezahlukeneyo zesakhiwo ezibalulekileyo kwizicelo zayo ezicetywayo kwisayensi yamayeza kunye neekhemikhali. Ukusetyenziswa kwiMichiza Le khompawundi ibonisa amandla athembisayo eyeza abangelwa ziimpawu zayo zesakhiwo. I-Pyrazole derivatives yaziwa ngemisebenzi yayo eyahlukeneyo yezamayeza, ukusuka kwiipropati ze-antimicrobial ukuya kwi-antitumor. Ukufakwa kweqela le-trifluoromethyl kunokutshintsha kakhulu umsebenzi webhayoloji kunye nozinzo lwe-metabolic, okunokuphucula ukusebenza kakuhle kwamayeza kunye neeprofayili zokhuseleko. Umsebenzi weBiological kunye neendlela Uphando lubonisa ukuba iikhompawundi ezithathelwe indawo yi-trifluoromethyl zihlala zibonisa ukuphuculwa kwe-lipophilicity kunye nokumelana ne-metabolic, okuchaphazela ukufunxwa kwazo, ukusasazwa, i-metabolism, kunye ne-excretion (ADME). Olu tshintsho lunokukhokelela ekuphuculweni kwe-bioavailability kunye neziphumo zonyango ezinde, okwenza ukuba zibe ngabaviwa abanomtsalane kuphuhliso lwamayeza. Iindlela zokwenziwa kunye nophuhliso Ukwenziwa kwe-1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid kubandakanya iinkqubo zamanyathelo amaninzi eziqala kwizinto zokuqala ezifumanekayo zorhwebo. Ukulungiswa kweendlela zokwenziwa kujolise ekuphuculeni isivuno, ubumsulwa, kunye nokukhula, okubalulekileyo kwizicelo zoshishino kunye nemveliso enkulu kwiindawo zamayeza. Uphando lwangoku kunye neMigqaliselo yexesha elizayo Uphando oluqhubekayo lugxile ekucaciseni uluhlu olupheleleyo lwemisebenzi yebhayoloji enxulumene ne-1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid. Oku kubandakanya ukuvavanya ukusebenza kwayo ngokuchasene neenjongo ezithile zesifo kunye nokwenza ngcono iifomyula zezilingo zeklinikhi. Izifundo zexesha elizayo zinokuhlola amandla ayo njengesakhiwo esisisiseko sokuyila abaviwa bamayeza amatsha abaneeprofayili ze-pharmacological ezilungiselelweyo. Ngamafutshane, i-1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid imele inkqubela phambili ebalulekileyo kwikhemistri yamayeza. Iimpawu zayo zolwakhiwo ezahlukeneyo kunye nemisebenzi ye-pharmacological enokubakho igxininisa ukubaluleka kwayo njengesihloko sophando lwesayensi oluqhubekayo kunye nophuhliso kuphuhliso lwamayeza.