I-2-Amino-3-(4-hydroxyphenyl)propanoic acid CAS:556-03-6

Impembelelo kwiSifo sikaParkinson: I-L-DOPA yeyona nyango isebenzayo yokunyanga isifo sikaParkinson. Isifo sikaParkinson sibangelwa kukunqongophala kwe-dopamine kwiindawo ezithile zobuchopho. I-L-DOPA yindlela yokuqala i-dopamine kwaye inokunqumla umqobo wegazi-ingqondo ukuze yonyuse amanqanaba e-dopamine, ngaloo ndlela inciphise iimpawu zesifo.

Ukusetyenziswa kwiSifo sikaParkinson: I-L-DOPA isetyenziswa rhoqo kunye ne-peripheral decarboxylase inhibitor (efana ne-carbidopa) ukuphucula ukusebenza kwayo. I-decarboxylase inhibitor ithintela ukuguqulwa kwe-L-DOPA ibe yi-dopamine kwizicubu ezingaphandle, ivumela i-L-DOPA engaphezulu ukuba ifikelele engqondweni.

Ulawulo lweempawu zeMoto: I-L-DOPA inceda ekunciphiseni iimpawu zeMoto ezinxulumene nesifo sikaParkinson, kubandakanya ukungcangcazela, ukuqina, i-bradykinesia (ukucotha kokuhamba), kunye nokungazinzi kwendlela yokuma. Iphucula ukusebenza kweMoto kwaye ivumela izigulane ukuba ziphinde zilawule iintshukumo zazo.

Iziphumo Ezingalindelekanga: Nangona i-L-DOPA isebenza kakuhle ekulawuleni iimpawu zikaParkinson, inokukhokelela nakwiziphumo ebezingalindelekanga ezininzi. Ezi zinokubandakanya i-dyskinesias (iintshukumo ezizenzekelayo), iingxaki zesisu (ezifana nokucaphuka, ukuhlanza, kunye nokuqhina), uxinzelelo lwegazi oluphantsi, ukubona izinto ezingekhoyo, kunye nokutshintsha kwemood. Iziphumo ebezingalindelekanga zinokuhluka ngobukhulu kwaye zifuna ukubekwa esweni ngononophelo kunye nokulungiswa komthamo wamayeza.

Ezinye iindlela zokusetyenziswa: Ngaphandle konyango lwesifo sikaParkinson, i-L-DOPA iye yahlolwa kwezinye iindlela zokusetyenziswa. Ibonakalise ukuba inamandla ekulawuleni i-restless leg syndrome, isifo esibonakaliswa kukunqwenela ukuhambisa imilenze, okukhokelela ekungonwabi nasekubeni nzima ukulala. I-L-DOPA inokuba nefuthe elihle kwiintlobo ezithile ze-dystonia, isifo sokuhamba kwemithambo-luvo.