(2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid CAS:132622-78-7

Uncedo olunemiba emininzi lwe-(2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid lukwizicelo zayo ezibanzi kuphando lwamayeza, ikhemistri yamayeza, kunye nokufunyanwa kwamayeza. Njengesakhiwo se-chiral, ibalulekile ekuphuhlisweni kweemolekyuli ezintsha zezinto eziphilayo kunye namayeza anokubakho. Abaphandi basebenzisa iimpawu zayo zesakhiwo ukuphonononga indima yayo ekuphuhliseni unyango olujolise kwizifo ezahlukeneyo, okunokukhokelela ekudalweni kweemveliso ezintsha zamayeza ezisebenza ngcono kunye neempawu eziphuculweyo ze-pharmacokinetic, ezibonelela ngeenzuzo ezinokubakho kwezempilo kunye namayeza. Ngaphezu koko, le khompawundi ifumana ukusetyenziswa kwi-peptide synthesis kunye ne-combinatorial chemistry, inegalelo ekudalweni kwe-peptidomimetics ezahlukeneyo kunye namayeza asekelwe kwi-peptide. Indalo yayo ye-chiral iyenza ibe luncedo ekuvelisweni kweepeptide ezithile ezineempawu ezilungiselelwe wena, yandisa ububanzi beendlela zonyango ezikhoyo kuphuhliso lwamayeza. Ukongeza, i-(2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid ixhasa ukuphononongwa kweempendulo ezintsha zeekhemikhali kunye nophuhliso lweendlela ezintsha zokwenziwa, inika abaphandi kunye neengcali zekhemistri isixhobo esiguquguqukayo sokwenza izakhiwo ezintsha zeemolekyuli. Uncedo lwayo olunemiba emininzi lugxininisa indima yalo ebalulekileyo ekuqhubeni uphuhliso kunye nophuhliso ngaphakathi kokwenziwa kwezinto eziphilayo, uphando lwamayeza, kunye nomzi-mveliso obanzi weekhemikhali, inika iindlela ezithembisayo zophuhliso lweemveliso ezintsha kunye nobuchwepheshe. Ngokubanzi, usetyenziso oluguquguqukayo lwekhompawundi luyibeka njengempahla exabisekileyo kuphando lwesayensi kunye nemisebenzi yemizi-mveliso.