(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid I-CAS:30246-33-4

(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, eyaziwa ngokuba yi [faka igama lorhwebo okanye igama eliqhelekileyo ukuba liyasebenza], ibaluleke kakhulu kuphando lwamayeza kunye nophuhliso lwamayeza ngenxa yeempawu zayo zokubulala iintsholongwane. Le khompawundi isebenza njengesiseko sokwakha izinto ezilwa neentsholongwane ezenzelwe ukujolisa kwiintlobo ezithile zeentsholongwane kunye nokuthintela ukukhula kwazo. Ulwakhiwo lwayo luvumela ukusebenzisana ngokuchanekileyo nee-enzymes zeentsholongwane, ukuphazamisa iinkqubo ezibalulekileyo kwaye kukhokelela kwiziphumo zokubulala iintsholongwane. Ngaphezu koko, i-(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid idlala indima ebalulekileyo ekulweni nosulelo lweebhaktheriya olusongela impilo yabantu. Ngokufaka le khompawundi kwimixube yee-antibiotic, abaphandi bajonge ukuphuhlisa iindlela ezintsha zonyango ezisebenza ngcono kunye nokuxhathisa okuncitshisiweyo. Indlela yokusebenza kwekhompawundi ijolise eludongeni lweeseli zebhaktheriya okanye ukwenziwa kweproteni, inika uluhlu olubanzi lomsebenzi ngokuchasene nebhaktheriya yeGram-positive kunye neGram-negative, kubandakanya iintlobo ezichasene namayeza amaninzi. Ngaphezu koko, imizamo yophando igxile ekuphuculeni iipropati ze-pharmacokinetic ze-(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid ukuphucula ukufumaneka kwayo kunye nokusasazwa kwayo emzimbeni. Le nkqubo yokwenza ngcono ibandakanya ukuphonononga amaqhinga ahlukeneyo okuhambisa amayeza, afana ne-prodrugs, i-nanoparticles, okanye ii-liposomal formulations, ukuphucula amandla okunyanga ekhompawundi kunye nokunciphisa iziphumo ebezingalindelekanga. Ukuqukumbela, i-(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid imele i-asethi exabisekileyo kwicandelo lonyango lwezifo ezisulelayo, inikezela ngezisombululo ezithembisayo zokujongana nokuxhathisa iintsholongwane kunye nokuphucula iziphumo zezigulane. Ukusetyenziswa kwayo ngeendlela ezahlukeneyo kunyango lwee-antibiotics kugxininisa ukubaluleka kwayo kunyango lwanamhlanje kwaye kugxininisa amandla ayo okukhuthaza uphuhliso lwe-antibiotics yesizukulwana esilandelayo.