I-Acetylcholinesterase CAS:9000-81-1

Ii-Anticholinesterases ludidi lwamayeza okanye iikhemikhali ezithintela umsebenzi we-enzyme i-acetylcholinesterase. I-Acetylcholinesterase inoxanduva lokuqhekeza i-neurotransmitter acetylcholine emzimbeni. Ngokuthintela le enzyme, ii-anticholinesterases zonyusa amanqanaba e-acetylcholine, nto leyo ekhokelela ekwandeni komsebenzi we-cholinergic kwiinkqubo zemithambo-luvo eziphakathi nezingaphandle.

Eyona ndlela iphambili yokusetyenziswa kwe-anticholinesterases kunyango lweengxaki zemithambo-luvo ezifana nesifo sika-Alzheimer kunye ne-myasthenia gravis. Kwisifo sika-Alzheimer, la mayeza ajolise ekuphuculeni i-cholinergic neurotransmission kwaye anokuthi anciphise ukuhla kwengqondo. Kwi-myasthenia gravis, i-anticholinesterases inceda ukuphucula i-neuromuscular transmission kunye namandla emisipha.

Ezinye iindlela zokusebenzisa i-anticholinesterases ziquka ukuxilongwa kunye nokunyangwa kwetyhefu ye-anticholinergic, ngakumbi evela kwii-insecticide okanye ii-nerve agents ezithile. Ezi zinto zinokubangela ukukhuthazwa okugqithisileyo kwe-muscarinic kunye ne-nicotinic receptors, okukhokelela kwiimpawu ezinje ngobuthathaka bemisipha, ukungcangcazela, kunye noxinzelelo lokuphefumla. I-Anticholinesterases inokuguqula ezi ziphumo ngokunyusa amanqanaba e-acetylcholine kunye nokukhuphisana nezinto ezinobuthi.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

Isiphumo se-anticholinesterase sibhekisa kubuchule bamachiza okanye iikhemikhali ezithile bokuthintela umsebenzi we-enzyme i-acetylcholinesterase. I-Acetylcholinesterase inoxanduva lokuqhekeza i-neurotransmitter acetylcholine emzimbeni. Ngokuthintela le enzyme, ii-anticholinesterase zonyusa amanqanaba e-acetylcholine, nto leyo ekhokelela ekwandeni komsebenzi we-cholinergic.

Ukusetyenziswa okuphambili kwe-anticholinesterases kunyango lweemeko ezibonakaliswa kukuncipha komsebenzi we-cholinergic. Ezi ziquka iingxaki ze-neurological ezifana nesifo se-Alzheimer kunye ne-myasthenia gravis. Kwisifo se-Alzheimer, ii-anticholinesterases ezifana ne-donepezil, i-rivastigmine, kunye ne-galantamine zisetyenziselwa ukuthintela ukuqhekeka kwe-acetylcholine kunye nokuphucula i-cholinergic neurotransmission. Oku kunokunceda ukuphucula ukusebenza kwengqondo kwaye kunokucothisa ukuqhubela phambili kwesi sifo.

Kwi-myasthenia gravis, ii-anticholinesterases ezifana neostigmine kunye ne-pyridostigmine zisetyenziselwa ukuphucula ukudluliselwa kwe-neuromuscular. La mayeza athintela i-acetylcholinesterase kwaye anyuse amanqanaba e-acetylcholine kwindawo yokudibana kwe-neuromuscular, ephucula amandla emisipha kwaye anciphise ubuthathaka bemisipha.

Ii-Anticholinesterases zikwanokusetyenziswa kokuxilonga kunye nokunyanga kwiimeko zetyhefu ye-anticholinergic. Iikhompawundi ze-Anticholinergic, ezifana nee-insecticide okanye ii-nerve agents ezithile, zinokubangela ukuvalelwa kwe-cholinergic okugqithisileyo okukhokelela kwiimpawu ezinje ngokudideka, ukubetha kwentliziyo ngokukhawuleza, umlomo owomileyo, kunye nokungaboni kakuhle. Kwiimeko ezinjalo, ii-anticholinesterases ezifana ne-pralidoxime zinokusetyenziselwa ukuguqula iziphumo ngokunyusa amanqanaba e-acetylcholine kunye nokukhuphisana nezinto ezinobuthi.

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	N / A
Uvavanyo	99%
Inkangeleko	Umgubo otyheli okhanyayo
Inombolo ye-CAS	9000-81-1
Ukupakisha	Encinci kwaye ininzi
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.