I-Acetylthiocholine iodide CAS:1866-15-5

I-acetylthiocholine iodide isetyenziswa kakhulu njengesiseko sokulinganisa umsebenzi we-enzyme i-acetylcholinesterase (AChE). I-AChE inoxanduva lokuqhekeza i-neurotransmitter acetylcholine kwinkqubo yemithambo-luvo. Ukongezwa kwe-acetylthiocholine iodide kumxube we-reaction oqulethe i-AChE kukhokelela kwimveliso ye-thiocholine kunye ne-acetate.

Impendulo ingafunyanwa ngokongeza isalathisi se-colorimetric okanye se-fluorometric esisabela ngokukodwa kwi-thiocholine. Izinga lokuveliswa kombala okanye kwe-fluorescence lihambelana ngqo nomsebenzi we-AChE kwisampuli. Oku kwenza i-acetylthiocholine iodide ibe sisixhobo esibalulekileyo sokulinganisa umsebenzi we-AChE kwiisampuli ezahlukeneyo zebhayoloji, kubandakanya izicubu, iinkcubeko zeeseli, kunye negazi.

Ukulinganiswa komsebenzi we-AChE kusetyenziswa i-acetylthiocholine iodide kusetyenziswa kakhulu kwizifundo zophando ezinxulumene neenkqubo ze-cholinergic, iingxaki ze-neurodegenerative, kunye nokuvezwa kwiikhemikhali okanye iziyobisi ezithile ezinokuchaphazela umsebenzi we-AChE. Ingasetyenziswa njengesixhobo sokuhlola ukufumanisa izithinteli ze-AChE, ezinomdla ekuphuhlisweni kwamayeza kwizifo ezifana ne-Alzheimer's kunye ne-Parkinson's.

Ukongeza ekusetyenzisweni kwiimvavanyo ze-enzyme, i-acetylthiocholine iodide ingasetyenziswa njengesiseko see-biosensors ezisekwe kwi-AChE. Ezi biosensors zenzelwe ukufumanisa nokulinganisa ubukho bezinto ezithile ezinokuthintela umsebenzi we-AChE, ezifana nee-pesticides ze-organophosphate okanye ii-nerve agents.