I-Adenosine CAS: 58-61-7

Kwishishini lezemithi, i-adenosine isetyenziselwa iipropati zayo zeyeza, ngakumbi ekunyangeni ii-arrhythmias ezithile zentliziyo. Ifakwa ngemithambo ukuze kubuyiselwe isigqi sentliziyo esiqhelekileyo ngexesha le-supraventricular tachycardia episodes. Ngaphezu koko, iziphumo ze-vasodilatory ze-adenosine zinegalelo ekusetyenzisweni kwayo kwiinkqubo zokuxilonga ezifana novavanyo loxinzelelo lwesifo semithambo yegazi yentliziyo, apho inceda ekukhuthazeni i-vasodilation elawulwayo yentliziyo ukuze kuvavanywe ukugeleza kwegazi kwentliziyo. Ngaphandle kokusetyenziswa kwentliziyo, i-adenosine isebenza njengenjongo ebalulekileyo ekuphuhlisweni kwamayeza, kunye nabaphandi abaphonononga amandla ayo okujongana neemeko eziqala kwizifo ze-neurodegenerative ukuya kumhlaza. Ukubandakanyeka kwayo ekulawuleni ukukhululwa kwe-neurotransmitter kunye nomsebenzi we-synaptic kukhokelele kuphando kunyango olusekelwe kwi-adenosine lweengxaki zemithambo-luvo kunye neemeko zengqondo. Ngaphezu koko, i-adenosine kunye nee-analogues zayo zifundwa ngeziphumo zazo ze-immunomodulatory, ezinefuthe kwizifo ze-autoimmune, ukudumba, kunye nonyango lokufakelwa. Ngokujolisa kwii-receptors ze-adenosine, abaphandi bajolise ekusebenziseni iipropati ze-immunosuppressive kunye ne-anti-inflammatory ze-adenosine njengesiseko sokuphuhlisa unyango olutsha. Ngamafutshane, iindima ezininzi ze-adenosine ezibandakanya imetabolism yamandla, umsebenzi wentliziyo, ukudluliselwa kwemithambo-luvo, kunye nokuguqulwa kwamasosha omzimba kugxininisa ukubaluleka kwayo kuphando lwamayeza kunye nokusetyenziswa konyango, okubonelela ngendlela etyebileyo yokuqhubela phambili ukungenelela kwezonyango kunye nokwandisa ukuqonda kwethu iindlela zeseli kunye nezomzimba.