I-Amphotericin B – Inqanaba le-CAS yenaliti: 1397-89-3

Inaliti ye-Amphotericin B isetyenziswa ekunyangeni izifo ezinzulu zefungus ezifana ne-candidemia, i-aspergillosis ehlaselayo, i-cryptococcal meningitis, kunye ne-mucormycosis, ngakumbi kwizigulana ezibuthathaka kumzimba okanye abo baneenkqubo zomzimba ezibuthathaka. Ngenxa yomsebenzi wayo onamandla wokulwa ne-fungus, inaliti ye-amphotericin B idla ngokuthathwa njengonyango lokuqala lwezifo ezinzulu zefungus. Iingcali zonyango zinika i-amphotericin B ngemithambo, zijonga ngononophelo izigulana ngexesha lokufakwa ukuze zilawule iziphumo ezibi ezinokubakho, kubandakanya umkhuhlane, ukubanda, kunye neempendulo ezinxulumene nokufakwa. Idosi kunye nobude bonyango lwe-amphotericin B zenzelwe usulelo oluthile lwefungus, imeko yempilo yesigulana, kunye nayo nayiphi na ingxaki yomzimba engaphantsi. Ngenxa yokuba ine-nephrotoxicity kunye nokuba ingadala ukuphazamiseka kwe-electrolyte, ukujonga ngokusondeleyo umsebenzi wezintso kunye namanqanaba e-electrolyte kubalulekile ngexesha lonyango lwe-amphotericin B. Iifomyula ze-lipid ze-amphotericin B zingasetyenziswa ukunciphisa ubuthi bezintso kunye neempendulo ezinxulumene nokufakwa ezinxulumene ne-amphotericin B deoxycholate eqhelekileyo. Ukujonga rhoqo iziphumo ezimbi, ezinje ngokungasebenzi kakuhle kwezintso kunye ne-hypokalemia, kunye nonyango olufanelekileyo oluxhasayo, kunceda ukulawula ukhuseleko kunye nokunyamezeleka konyango lwe-amphotericin B. Ababoneleli bezempilo bajonga ngononophelo izibonelelo zonyango ngokuchasene neengozi ezinokubakho, beqinisekisa ukuba izigulana zifumana unyango olufanelekileyo lwe-antifungal ngelixa zinciphisa impembelelo yeziphumo ezimbi. Ngokujonga ngempumelelo usulelo olukhulu lwe-fungus, i-amphotericin B injection idlala indima ebalulekileyo ekujongeni iimeko ezisongela ubomi kunye nokubonelela ngeendlela zonyango kwizigulana ezijongene nezifo ze-fungus ezinzima.