I-Ansamycin CAS:72559-06-9

Ii-Ansamycins, ezifana ne-rifamycins, zisetyenziswa kakhulu kwizonyango ukunyanga iintlobo ngeentlobo zezifo ezibangelwa yintsholongwane, kubandakanya isifo sephepha, iqhenqa, kunye neentlobo ezithile zezifo ezibangelwa yi-staphylococcal kunye ne-streptococcal. I-Rifampin, i-rifamycin eyaziwayo, idla ngokusetyenziswa njengenxalenye yonyango oludibeneyo lwesifo sephepha kunye nezinye izifo ezibangelwa yi-mycobacterial. Indlela esebenza ngayo i-ansamycins ibandakanya ukubopha kwi-RNA polymerase yebhaktiriya, ngaloo ndlela ithintela ukubhalwa kwayo kwaye ekugqibeleni ikhokelele ekufeni kweeseli zebhaktiriya. Le ndlela ikhethekileyo yokusebenza yenza i-ansamycins isebenze ngokuchasene noluhlu olubanzi lweebhaktiriya ezine-Gram-positive kunye ne-Gram-negative. Ababoneleli bezempilo baqwalasela ngononophelo izinto ezifana nohlobo losulelo, imbali yezonyango yesigulana, kunye neziphumo zovavanyo lokuthambekela kwintsholongwane xa benika ii-ansamycins. Idosi efanelekileyo, ixesha lonyango, kunye nokubeka iliso kwiziphumo ebezingalindelekanga ezinokubakho kubalulekile ekwandiseni izibonelelo zonyango ngelixa kunciphisa iingozi ezinxulumene nokusetyenziswa kwee-antibiotics. Iziphumo ezimbi ezinxulumene ne-ansamycins zinokubandakanya ukuphazamiseka kwesisu, ubuthi besibindi, kunye nokusabela kwe-hypersensitivity. Ukujonga rhoqo uvavanyo lokusebenza kwesibindi kunye nokujonga ngokusondeleyo naziphi na iimpawu zempendulo embi kunceda ukuqinisekisa ukusetyenziswa ngokukhuselekileyo nangokusebenzayo kwe-ansamycins kunyango lwezifo ezibangelwa yintsholongwane. Ngokubanzi, ii-ansamycins zimele udidi oluxabisekileyo lwee-antibiotics ezinezicelo ezahlukeneyo ekulawuleni izifo ezibangelwa yintsholongwane. Ngokusebenzisa nokubeka esweni ngokufanelekileyo, iingcali zonyango zinokusebenzisa iipropati ze-ansamycins zokulwa nentsholongwane ukulwa nosulelo ngokufanelekileyo kunye nokuphucula iziphumo zesigulana.