I-Avibactam sodium CAS:1192491-61-4

I-Avibactam sodium isetyenziswa kwizonyango njenge-beta-lactamase inhibitor ukubuyisela ukusebenza kakuhle kwee-antibiotics ezithile nxamnye neebhaktheriya ezinganyangekiyo ngamayeza amaninzi. Idla ngokudityaniswa nee-antibiotics ezifana ne-ceftazidime ukwenza iindibaniselwano zedosi ezimiselweyo ezijolise kwiintlobo ezahlukeneyo zeentsholongwane ze-Gram-negative, kubandakanya i-Enterobacteriaceae kunye ne-Pseudomonas aeruginosa. Ababoneleli bezempilo banika ii-antibiotics eziqulethe i-avibactam sodium kwiintsholongwane ezinzima zangaphakathi esiswini, izifo zomchamo, i-pneumonia efunyenwe esibhedlele, kunye nezinye izifo ezinzulu zebhaktheriya ezibangelwa zizinto eziphilayo ezinganyangekiyo kwii-antibiotics eziqhelekileyo. Ukongezwa kwe-avibactam sodium kunceda ukoyisa iindlela zokuxhathisa iibhaktheriya, ukubuyisela ukusebenza kakuhle kwee-antibiotics ekulweni nezifo ezinzima ukunyanga. Iindlela zokulinganisa ezibandakanya i-avibactam sodium zenzelwe ngokusekelwe kusulelo oluthile, izinto zesigulana, iziphumo zovavanyo lokuthambekela, kunye nomxube we-antibiotic osetyenzisiweyo. Ukujonga ngokusondeleyo impendulo yonyango, iipatheni zokuthambekela kwiintsholongwane, kunye nemiphumo emibi enokubakho kubalulekile ukuqinisekisa iziphumo zonyango ezifanelekileyo kunye nokunciphisa umngcipheko wokungaphumeleli konyango. Iziphumo ezimbi ezinxulumene nee-antibiotics eziqulethe i-avibactam sodium zinokubandakanya ukuphazamiseka kwesisu, ukusabela kwe-hypersensitivity, kunye nemingcipheko enxulumene nokusetyenziswa ngaxeshanye kwee-antibiotics. Ababoneleli bezempilo kufuneka baqwalasele iimpawu zesigulana ngasinye kunye nokusebenzisana kwamayeza xa benika ezi ndibaniselwano ukuze kuphuculwe ukusebenza kakuhle konyango kunye nokhuseleko. Ngokudibanisa i-avibactam sodium kunye nee-antibiotics ezifanelekileyo, iingcali zezempilo zinokujongana ngempumelelo nosulelo lweebhaktheriya olunzima oluchasene namayeza amaninzi, zinike izigulana ezinye iindlela zonyango kunye nokuphucula iziphumo zeklinikhi ekulawuleni izifo ezintsonkothileyo.