i-beta-Nicotinamide adenine dinucleotide trihydrate CAS:53-84-9

Ukuveliswa kwamandla: I-β-NAD+ yinxalenye ebalulekileyo kwinkqubo yokuguqula ukutya kube ngamandla. Isebenza njenge-coenzyme ekuphefumleni kweeseli, inceda ekudluliseleni kwee-elektroni ukusuka kwi-metabolites ukuya kwikhonkco lokuthutha ii-elektroni. Olu dluliselo lwee-elektroni lubalulekile ekudalweni kwe-ATP, eyimali yamandla ephambili kwiiseli.

Ukulungiswa kwe-DNA: I-β-NAD+ ibandakanyeka kwiinkqubo zokulungiswa kwe-DNA. Isebenza njengesiseko see-enzymes ezifana nee-PARPs (i-Poly [ADP-ribose] polymerases), ezisebenzisa i-β-NAD+ ukulungisa i-DNA eyonakeleyo ngenxa yoxinzelelo lweeseli ezahlukeneyo ezifana nomonakalo we-DNA obangelwa yimitha, iityhefu, okanye uxinzelelo lwe-oxidative.

Ukuhanjiswa kwemiqondiso yeseli: I-β-NAD+ ivele njengemolekyuli ebalulekileyo yokuhanjiswa kwemiqondiso ebandakanyeka kwiindlela ezahlukeneyo zeseli. Ingasebenza njengomphambili weemolekyuli ezahlukeneyo zokuhanjiswa kwemiqondiso, njenge-cyclic ADP-ribose kunye ne-NAADP, ezilawula ukukhululwa kwe-calcium kunye nokudluliselwa kwemiqondiso. Ukongeza, imetabolism ye-β-NAD+ inokuchaphazela ukubonakaliswa kwezakhi zofuzo, ukwaluphala, kunye nezinye iinkqubo zomzimba.

Izicelo zonyango: Ukongezwa kwe-β-NAD+ kunye nokuguqulwa kwamanqanaba e-β-NAD+ kuyaphandwa ukuze kufunyanwe izicelo zonyango ezinokubakho. Izifundo zakutshanje zibonisa ukuba ukunyuka kwamanqanaba e-β-NAD+ kunokuba nemiphumo emihle kwizifo ezinxulumene nokwaluphala, iingxaki ze-neurodegenerative, iingxaki ze-metabolic, kunye nempilo yentliziyo. Kukwakho nophando oluqhubekayo malunga nokusetyenziswa kwezinto ezisandula ukwenziwa ze-β-NAD+, ezifana ne-nicotinamide riboside kunye ne-nicotinamide mononucleotide, njengezongezo ezinokubakho zokunyusa amanqanaba e-β-NAD+ emzimbeni.