I-Bethahistinemethanesulfonate CAS:54856-23-4

I-Bethahistinemethanesulfonate isetyenziswa kakhulu kwicandelo lezonyango, ngokukodwa ngenxa yezibonelelo zayo zonyango ekunyangeni iingxaki ze-vestibular ezifana nesifo sikaMeniere kunye nezinye iimeko ezinxulumene nokulinganisela. Isifo sikaMeniere siquka iziganeko ze-vertigo, i-tinnitus, kunye nokulahlekelwa kukuva, okubangelwa kukungasebenzi kakuhle kolwelo kwindlebe yangaphakathi. Ukunikwa kwe-Bethahistinemethanesulfonate kunokunceda ukunciphisa ezi mpawu ngokuphucula ukuhamba kwegazi ukuya endlebeni yangaphakathi, ngaloo ndlela kuzinzisa inkqubo ye-vestibular kwaye kuncitshiswe ukuphindaphindeka kunye nobunzima beziganeko ze-vertiginous. Ukongeza kwiingxaki ze-vestibular, i-Bethahistinemethanesulfonate inokuba luncedo ekunyangeni ezinye iimeko ezinxulumene nokuphazamiseka kokujikeleza kwegazi. Ngokusebenza njenge-vasodilator, inceda ukuphucula ukuhamba kwegazi kwiithishu ezahlukeneyo, iyenze ibe luncedo kwizigulana ezinezifo zemithambo yegazi. Olu phuculo lokujikeleza kwegazi lunokuphucula ukuhanjiswa kweoksijini kunye nezondlo kwiindawo ezichaphazelekayo, lukhuthaze ukuphiliswa kunye nokusebenza ngcono. Ngaphezu koko, uphando lubonise ukusetyenziswa okunokwenzeka kwe-Bethahistinemethanesulfonate ekukhuseleni imithambo-luvo kunye nokuphucula ingqondo. Isenzo sayo njenge-histamine receptor agonist sibonisa ukuba inokudlala indima ekulawuleni ukukhululwa kwe-neurotransmitter, ngaloo ndlela ichaphazela iinkqubo zengqondo kwaye inike iziphumo zokukhusela i-neurotransmitter kwizifo ze-neurodegenerative. Le compound ingaqwalaselwa nokusetyenziswa kwezinye iimeko, njengakwimeko yokunyanga ii-allergy ezithile ngenxa yomsebenzi wayo we-histamine. Nangona kunjalo, ukusetyenziswa kwayo kule ndawo kufuna uphando olongezelelekileyo kunye nokuqinisekiswa. Ngokubanzi, iBethahistinemethanesulfonate yiarhente yonyango eguquguqukayo eyaziwayo ngemiphumo yayo emihle kumsebenzi we-vestibular kunye nokujikeleza kwegazi, ibonisa ithemba kwizicelo ezahlukeneyo zonyango ezigxile ekuphuculeni umgangatho wobomi besigulana.