I-Bis(2-chloroethyl)aminehydrochloride CAS:821-48-7

I-Bis(2-chloroethyl)amine hydrochloride inezicelo ezibalulekileyo kwi-oncology nakwi-chemotherapy. Njenge-arhente ye-alkylating, iphazamisa ukuphindaphindwa kwe-DNA kunye nokwahlukana kweeseli, okwenza ibe yi-cytotoxic kwiiseli ezanda ngokukhawuleza, kuquka neeseli zomhlaza. Le propati ikhokelele ekuphuhlisweni kwee-mustard ze-nitrogen njengee-arhente ze-chemotherapeutic zokunyanga izifo ezahlukeneyo ze-neoplastic. Enye yeendlela eziphambili zokusetyenziswa kwe-bis(2-chloroethyl)amine hydrochloride kunyango lweentlobo ezithile zomhlaza, ezifana ne-lymphoma, i-leukemia, kunye nee-tumor eziqinileyo. Ngokonakalisa i-DNA yeeseli zomhlaza, le khompawundi inokubangela ukufa kweeseli kwaye ithintele ukukhula kwe-tumor, inceda ekunciphiseni okanye ekupheliseni ii-massaging masses kwizicubu ezichaphazelekayo. Ngaphezu koko, i-bis(2-chloroethyl)amine hydrochloride isetyenziswa kwiilabhoratri zophando ukuze ifunde iindlela zokusebenza kwee-arhente ze-alkylating kunye nokuphonononga usetyenziso lwazo olunokwenzeka lonyango. Izazinzulu ziphanda ukusebenzisana kweemolekyuli phakathi kwe-nitrogen mustard kunye neenxalenye zeseli ukuphucula amaqhinga okunyanga umhlaza kunye nokuphuhlisa amayeza asebenzayo ngakumbi. Ngaphezu koko, le khompawundi isetyenziswa kwizifundo zangaphambi kweklinikhi kunye novavanyo lweklinikhi ukuvavanya ukusebenza kwayo kunye nokhuseleko kwizigulane zomhlaza. Ngokuvavanya iprofayili yezonyango kunye nomsebenzi wokulwa nomhlaza we-bis(2-chloroethyl)amine hydrochloride, abaphandi bajonge ukumisela indima yayo kwiinkqubo zanamhlanje ze-oncology kunye nokuphucula iindlela zonyango lwezifo ezithile zesifo somhlaza. Ukuqukumbela, i-bis(2-chloroethyl)amine hydrochloride idlala indima ebalulekileyo kunyango lomhlaza kunye nophando lwezonyango, inika amathuba amatsha okulwa nezifo ezinobungozi kunye nokuphucula ukuqonda kwethu iiarhente zokulwa nomhlaza. Ubuthi bayo obukhethiweyo kwiiseli zomhlaza bugxininisa ukubaluleka kwayo kuphuhliso lonyango olutsha lokuphucula iziphumo zesigulana kunye nomgangatho wobomi.