I-Boc-Trp-OSu CAS:3392-11-8

I-Boc-Trp-OSu ibalulekile kwi-bioconjugation chemistry, ngakumbi ekusebenzeni kweepeptides kunye neeproteni kwizicelo ezijoliswe kuzo. Njenge-NHS ester derivative, yenza kube lula ukudibanisa i-covalent ye-Boc-protected tryptophan moiety kunye nee-primary amines ezikhoyo kwi-amino acids, iipeptides, okanye iiproteni. Olu kudibanisa olukhethiweyo luvumela ukuguqulwa ngokuchanekileyo kwee-amino acid residues ezithile ngaphakathi kolandelelwano lwe-peptide okanye i-N-terminus yeproteni, okuvumela ukungeniswa kwamaqela asebenzayo okanye iilebhile ngeenjongo ezahlukeneyo. Abaphandi kunye neengcali ze-biochemists basebenzisa i-Boc-Trp-OSu ekuphuhlisweni kwee-peptide conjugates kwizicelo ezinje ngokuhanjiswa kwamayeza ajoliswe kuwo, ii-immunoassays, kunye nokusebenza kwezinto eziphilayo. Ngokudibanisa iipeptides eziguqulweyo ze-Boc-Trp-OSu kwiimolekyuli okanye kwiindawo ezijolise kuzo, banokwenza izakhiwo ze-bioactive ezikwaziyo ukusebenzisana ngokukhethayo nee-receptors zeseli, ii-antigens, okanye ii-biological matrices. Ukongeza, iBoc-Trp-OSu isetyenziswa ekulungiseleleni ii-peptide-protein conjugates zokuvelisa ii-antibody-drug conjugates (ii-ADC) kunye neelebhile zeproteni zokujonga imifanekiso kunye novavanyo lokuxilonga. Ukuguquguquka kweBoc-Trp-OSu kuyenza ibe sisixhobo esibalulekileyo kwiinkalo ezahlukeneyo ezifana nebhayoloji yamakhemikhali, i-biotechnology, kunye nesayensi yamayeza. Ukuhambelana kwayo nemigaqo ye-bioconjugation, ukusebenza okuphezulu, kunye nokukhetha kunegalelo ekusetyenzisweni kwayo ngokubanzi kwiindawo zemfundo nakwimizi-mveliso. Nokuba isetyenziswa kuphando olusisiseko okanye kuphuhliso lwezonyango eziphambili, iBoc-Trp-OSu ivumela ukudalwa kwee-peptide conjugates ezenzelwe wena ezibalulekileyo ekuphuculeni unyango olujolise kuzo kunye nokuxilongwa kweemolekyuli.