I-Candesartan CAS: 139481-59-7 uMboneleli woMvelisi

I-Candesartan ngumchasi we-angiotensin II receptor I (AT1), i-IC50s=1.12 kunye ne-2.86 nM ye-bovine adrenal cortex kunye ne-aorta yomvundla ngokulandelelana.Inqanda ngokukhethayo i-angiotensin II-i-induced contraction ye-rabbit aortic strips ingenayo impembelelo kwi-contraction ye-nopinephrine , i-KCl, i-serotonin, i-PGF2αokanye i-endothelin.

Iodolo okanye Cela iQuote

Iinkcukacha zeMveliso

Iithegi zeMveliso

Isicelo kunye nesiphumo

I-Candesartan i-AT1 ekhethiweyo (i-angiotensin II receptor 1) inchasi.I-Antagonism ye-angiotensin receptors inqanda i-vasoconstriction kunye nokuveliswa kwe-aldosterone, ekhokelela ekunciphiseni kwamanzi kunye ne-sodium concentration kwi-plasma yegazi.Ubonisa iziphumo ze-antihypertensive kwiimodeli zezilwanyana.Isetyenziswa kunyango lwe-congestive heart failure, njenge-antihypertensive.I-Candesartan ayichaphazeli ukusebenza kweeseli okanye ukwanda kodwa yonyusa ukubonakaliswa kwe-VEGF kunye ne-interleukin-8 kwindlela yokukhuliswa kweeseli ze-KU-19-19.I-Candesartan (0.1 nM) inokunciphisa ubukhulu besivumelwano sokuphendula kwi-angiostensin II malunga ne-50%.

Isampulu yeMveliso

Ukupakishwa kweMveliso:

Iinkcukacha ezongezelelweyo:

Ukuqamba	I-C24H20N6O3
Isivavanyi	99%
Imbonakalo	Umgubo omhlophe
Inombolo yeCAS.	139481-59-7
Ukupakisha	1KG 25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.