I-Candesartan CAS:139481-59-7 Umthengisi woMvelisi Umfanekiso oPhambili

Umthengisi woMvelisi weCandesartan CAS:139481-59-7

I-Candesartan yi-angiotensin II receptor I (AT1) antagonist, i-IC50s=1.12 kunye ne-2.86 nM ye-bovine adrenal cortex kunye ne-rabbit aorta ngokwahlukeneyo. Ithintela ngokukhetha ukucutheka okubangelwa yi-angiotensin II kwi-rabbit aortic strips ngaphandle kwefuthe ekucuthekeni okubangelwa zezinye izinto ezifana ne-norepinephrine, i-KCl, i-serotonin, i-PGF2α okanye i-endothelin.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

I-Candesartan yi-AT1 ekhethiweyo (i-angiotensin II receptor 1). Ukuchasana kwee-angiotensin receptors kuthintela ukuxinana kwegazi kunye nokuveliswa kwe-aldosterone, okukhokelela ekunciphiseni koxinzelelo lwamanzi kunye ne-sodium kwi-plasma yegazi. Ibonisa iziphumo zokulwa noxinzelelo lwegazi kwiimodeli zezilwanyana. Isetyenziswa kunyango lokusilela kwentliziyo okuxineneyo, njenge-antihypertensive. I-Candesartan ayichaphazeli ukuphila okanye ukwanda kweeseli kodwa inyusa ukubonakaliswa kwe-VEGF kunye ne-interleukin-8 kwindawo ekhuliswe kwiiseli ze-KU-19-19. I-Candesartan (0.1 nM) inokunciphisa impendulo ephezulu yokuxinana kwi-angiostensin II malunga ne-50%.

Isampuli yeMveliso

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	C24H20N6O3
Uvavanyo	99%
Inkangeleko	Umgubo omhlophe
Inombolo ye-CAS	139481-59-7
Ukupakisha	1KG 25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.