I-CAS yeClascoterone: 19608-29-8 uMboneleli woMvelisi

I-Clascoterone yi-androgen receptor inhibitor ephuhliswa njenge-cream cream kunye nesisombululo nguCassiopea (inkampani ye-spin-out ye-Cosmo Pharmaceuticals) yonyango lweengxaki zesikhumba ezixhomekeke kwi-androgen, kuquka i-androgenetic alopecia kunye ne-acne vulgaris.Nangona eyona ndlela ichanekileyo yokwenza i-clascoterone yonyango lwe-acne vulgaris ingaziwa, iyeza kukholelwa ukuba likhuphisana ne-androgen dihydrotestosterone yokubophelela kwi-androgen receptors kwi-sebaceous gland kunye ne-follicles yeenwele ukunciphisa umqondiso oyimfuneko kwi-acne pathogenesis.

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Isicelo kunye nesiphumo

I-Clascoterone iphuhliswa njengokhilimu we-topical nguCassiopea ngenxa yeengxaki zesikhumba ezixhomekeke kwi-androgen.I-Clascoterone (i-cortexolone 17α-propionate, i-CB-03-01) ngumchasi we-noveli we-androgen receptors.Ibophelela kwi-androgen receptors kunye nobudlelwane obuphezulu.Ngokukhuphisana kunye ne-androgens yokubophelela kwi-androgen receptors, i-clascoterone isebenza ngokuthintela i-androgen receptor signaling cascades ekhuthaza i-acne pathogenesis, njengokwanda kwe-sebaceous gland, ukuveliswa kwe-sebum engaphezulu, kunye neendlela ezivuthayo.Ngo-Agasti ka-2020, i-FDA yavuma i-clascoterone yonyango lokuqala lwe-acne (acne vulgaris) kwizigulane zamadoda nabasetyhini abaneminyaka eyi-12 nangaphezulu.I-Clascoterone nayo iphandwa njengonyango lwe-androgenetic alopecia.

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Iinkcukacha ezongezelelweyo:

Ukuqamba	C24H34O5
Isivavanyi	99%
Imbonakalo	Umgubo omhlophe
Inombolo yeCAS.	19608-29-8
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.