Umthengisi weSimvastatin CAS:79902-63-9

I-Simvastatin yenziwe kancinci, ayithandi manzi, ifana ne-lovastatin. Njenge-lovastatin, i-simvastatin sisithinteli esithile se-HMG-CoA reductase kwaye isetyenziswa ngonyango ukunciphisa i-LDL cholesterol. Kutshanje, ii-statins ziye zaba ziiprobe ezibalulekileyo ze-biochemical kwi-biology yeseli. Ukubandakanyeka kwazo kwiziganeko ezininzi kunokunxulunyaniswa nendlela yazo yokuqala yokusebenza, nangona kunjalo, indlela yokusebenza kwezinye iziphumo ezininzi ayibonakali kangako. I-Simvastatin sisithinteli esithile se-HMG-CoA reductase, i-enzyme ekhuthaza ukuguqulwa kwe-HMG-CoA ibe yi-mevalonate, inyathelo lokuqala kwi-cholesterol biosynthesis. Isetyenziswa kunyango lwe-hypercholesterolemia, njengoko inciphisa amanqanaba e-low-density lipoproteins kunye ne-triglycerides, kwaye inyusa amanqanaba e-high-density lipoproteins.