I-Setmelanotide CAS:920014-72-8 Umthengisi woMvelisi

I-Setmelanotide yi-agonist ye-melanocortin-4 receptor (MC4R). Ukusetyenziswa kwayo kuquka unyango lweengxaki ezithile zemfuza ezinxulumene nokutyeba kakhulu, ezifana nokungabikho kwe-pro-opiomelanocortin (POMC), ukungabikho kwe-leptin receptor (LEPR), kunye ne-Bardet-Biedl syndrome. I-Setmelanotide isetyenziselwa ukulawula ukutyeba kakhulu kwizigulana ezinezi meko ezithile zemfuza, ngokunceda ukulawula inkanuko yokutya kunye nobunzima bomzimba. Iziphumo ebezingalindelekanga eziqhelekileyo ziquka ukusabela kwindawo yokufaka inaliti, i-hyperpigmentation yesikhumba (amabala esikhumba amnyama kunesikhumba esijikelezileyo), intloko ebuhlungu kunye nemiphumo emibi yesisu (njengesicaphucaphu, urhudo, kunye nentlungu yesisu), phakathi kwezinye. Ukuqina kwepenile okuzenzekelayo kumadoda kunye nemiphumo emibi yesondo kubasetyhini kuye kwenzeka ngonyango. Ukudakumba kunye neminqweno yokuzibulala kuye kwenzeka nakwi-setmelanotide.