I-Dehydrogenase, utywala I-CAS:9031-72-5 Ixabiso lomenzi

Ii-dehydrogenases liqela lee-enzymes ezikhuthaza i-oxidation ye-substrate ngokususa ii-athomu ze-hydrogen. Xa kufikwa kwi-alcohol dehydrogenase, isebenza ngokukodwa kwi-alcohols, iququzelela ukuguqulwa kwazo zibe yi-aldehydes okanye ii-ketones ngokususa ii-athomu ze-hydrogen.

Ngokuphathelele impembelelo yotywala, i-alcohol dehydrogenase idlala indima ebalulekileyo kwi-metabolism ye-ethanol emzimbeni womntu. Inceda ekuqhekezeni i-ethanol ibe yi-acetaldehyde, ethi emva koko ixutywe ibe yi-acetic acid. Le nkqubo ibalulekile ekuthinteleni ukuqokelelwa kwamanqanaba anetyhefu e-ethanol emzimbeni. Nangona kunjalo, ukusela utywala kakhulu kunokugqithisa amandla e-alcohol dehydrogenase, okubangela ukwakheka kwe-acetaldehyde, enxulunyaniswa neempawu ezingathandekiyo ezaziwa ngokuba yi-alcohol flush reaction.

Ngokwendlela ezisetyenziswa ngayo, i-alcohol dehydrogenase ineendlela ezininzi ezibalulekileyo zokusetyenziswa. Isetyenziswa kakhulu ekuveliseni i-ethanol kwishishini lokubilisa. Le enzyme isetyenziselwa ukuphembelela ukuguqulwa kweswekile ibe yi-ethanol yimvubelo okanye iibhaktheriya. Ngaphezu koko, i-alcohol dehydrogenase isetyenziswa kwiindlela ezahlukeneyo zelebhu kunye novavanyo lokuxilonga. Isetyenziselwa ukulinganisa amanqanaba otywala kwiimvavanyo zokuphefumla kunye novavanyo lomxholo wotywala egazini (BAC). Ngaphezu koko, ifumana ukusetyenziswa ekuveliseni iikhemikhali, ezinje ngee-organic acids kunye nee-esters, ngeenkqubo ze-biocatalysis.