i-dUMP, i-2′-Deoxyuridine-5′-monophosphate, ityuwa ye-disodium CAS:42155-08-8 Umfanekiso obonisiweyo

i-dUMP, i-2′-Deoxyuridine-5′-monophosphate, ityuwa ye-disodium I-CAS:42155-08-8

I-2′-Deoxyuridine-5′-monophosphate (dUMP) sisithako se-nucleotide esibandakanyeka ekuqulunqweni nasekulungisweni kwe-DNA. Isebenza njengomanduleli we-dTTP (deoxythymidine triphosphate), esisithintelo esiyimfuneko sokwenziwa kwe-DNA kwakhona. I-dUMP ikwayinxalenye ebalulekileyo kwinkqubo ye-thymidylate biosynthesis, apho iguqulwa ibe yi-dTMP (deoxythymidine monophosphate) yi-enzyme thymidylate synthase. Olu tshintsho lubalulekile ekugcineni ibhalansi ye-nucleotide efanelekileyo kunye nokuthembeka kwe-DNA kwiiseli.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

Ukwenziwa kwe-DNA: i-dUMP isebenza njengomqalisi we-deoxythymidine triphosphate (dTTP), ebalulekileyo ekuphindaphindweni kwe-DNA. Ukuguqulwa kwe-dUMP ibe yi-dTMP linyathelo elibalulekileyo ekuqulunqweni kwee-nucleotides ze-thymidine, ezibalulekileyo ekuphindaphindweni ngokuchanekileyo kwezinto zemfuza ngexesha lokwahlukana kweseli.

I-Thymidylate Biosynthesis: i-dUMP yi-substrate ye-enzyme i-thymidylate synthase, ekhuthaza ukuguqulwa kwe-dUMP ibe yi-dTMP. Le nkqubo ibalulekile ekugcineni ibhalansi ye-nucleotide efanelekileyo kwiiseli kunye nokuqinisekisa ukuthembeka kokuphindaphinda kwe-DNA.

Ithagethi yeyeza lokulwa nomhlaza: I-Thymidylate synthase, i-enzyme ebandakanyekayo ekuguqulweni kwe-dUMP ibe yi-dTMP, yindawo ekujoliswe kuyo amayeza athile okulwa nomhlaza. Ukuthintela i-thymidylate synthase kunokuphazamisa ukwenziwa kwe-DNA kunye nokwanda kweeseli, okwenza ukuba ibe yindawo ekujoliswe kuyo kwi-chemotherapy.

Isixhobo soPhando: i-dUMP isetyenziswa kuphando lwebhayoloji yebhayoloji kunye neyemolekyuli njengesiseko sokufunda iindlela zokwenziwa kwe-DNA, ukulungiswa, kunye ne-metabolism ye-nucleotide. Ikwasetyenziswa kwiimvavanyo ze-enzyme ukuphanda umsebenzi we-thymidylate synthase kunye nee-enzymes ezinxulumene noko.

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	C9H14N2NaO8P
Uvavanyo	99%
Inkangeleko	Umgubo omhlophe
Inombolo ye-CAS	42155-08-8
Ukupakisha	Encinci kwaye ininzi
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.