I-Ethionamide CAS:536-33-4

I-Ethionamide yinxalenye ebalulekileyo ekulawuleni isifo sephepha esinganyangekiyo ngamayeza amaninzi (MDR-TB) kunye nesifo sephepha esinganyangekiyo ngamayeza amaninzi (XDR-TB), iintlobo ezimbini zesifo sephepha ezinganyangekiyo ngamayeza aqhelekileyo. Le antibiotic idla ngokusetyenziswa njengenxalenye yenkqubo yonyango ebanzi equka amayeza amaninzi okulwa nosulelo lwe-TB olubangelwa ziintlobo ezinganyangekiyo ngamayeza. I-Ethionamide isebenza ngokuphazamisa ukwenziwa kwe-mycolic acids ngaphakathi kodonga lweseli yebhaktiriya yesifo sephepha iMycobacterium, ngaloo ndlela ithintela ukukhula nokuphindaphinda kwebhaktiriya. Kubalulekile ukulandela idosi emiselweyo kwaye ugqibezele ikhosi epheleleyo yonyango ukuze ufumane iziphumo zonyango ezifanelekileyo kwaye uthintele uphuhliso lokunganyangeki ngamayeza ngakumbi. Iziphumo eziqhelekileyo ze-ethionamide zinokubandakanya imiba yesisu efana nokugabha, ukuhlanza, kunye nentlungu yesisu, kunye neempawu zemithambo-luvo ezifana ne-peripheral neuropathy. Ukuhlolwa rhoqo ngababoneleli bezempilo kuyimfuneko ukuvavanya ukusebenza kakuhle konyango kunye nokulawula naziphi na iziphumo ezimbi ngokukhawuleza. Izigulana kufuneka zilandele ngokungqongqo irejimeni yazo yonyango kunye nokuqeshwa okulandelayo ukuze zijonge inkqubela phambili kwaye ziqinisekise ukuba ziyaphila ngempumelelo kwisifo sephepha. I-Ethionamide idlala indima ebalulekileyo ekulweni nesifo sephepha esinganyangekiyo ngamayeza kwaye igxininisa ukubaluleka kwendlela yokusebenzisa amayeza amaninzi ekusombululeni umthwalo wehlabathi wesi sifo esosulelayo.