I-Fidaxomicin CAS:873857-62-6

I-Fidaxomicin isetyenziswa kakhulu kunyango losulelo lweClostridioides difficile, ingakumbi kwiimeko ze-CDI ephakathi ukuya kweyomeleleyo apho unyango lwendabuko belungaphumeleli kakuhle okanye lunxulunyaniswa namazinga aphezulu okubuyela kwesi sifo. Isetyenziswa ngomlomo kwifomu yethebhulethi, ivumela ukuhanjiswa okujoliswe kuyo kwindawo yosulelo kwikholoni. Indlela eyahlukileyo yokusebenza kwe-fidaxomicin ibandakanya ukuthintela i-RNA polymerase yebhaktheriya, ukuphazamisa ukwenziwa kweproteni kwiiseli ze-C. difficile. Ngokujolisa le pathogen ithile ngaphandle kokuchaphazela i-microbiota eluncedo yamathumbu, i-fidaxomicin inceda ukubuyisela ibhalansi yeentsholongwane kwikholoni kwaye inciphise umngcipheko weziganeko ze-CDI eziphindaphindayo. Izigulana ezinosulelo lwe-C. difficile eziqinisekisiweyo okanye ezirhanelwayo zihlala zinikwa i-fidaxomicin ixesha elithile ngokuxhomekeke kubukhali bosulelo. Ukunamathela kwidosi emiselweyo kunye nerejimeni kubalulekile ekufezekiseni iziphumo ezilungileyo zeklinikhi kunye nokunciphisa umngcipheko wokubuyela kwesi sifo. Iziphumo ebezingalindelekanga eziqhelekileyo zinokubandakanya isicaphucaphu, iintlungu zesisu, kunye nokuphazamiseka kwesisu; nangona kunjalo, i-fidaxomicin ngokubanzi ibonisa ukunyamezeleka okuhle xa kuthelekiswa nezinye iindlela zonyango ze-CDI. Ukubeka iliso rhoqo ngexesha lonyango kunye novavanyo olulandelayo emva konyango kubalulekile ukuvavanya impendulo, ukujonga iimpendulo ezingalunganga, kunye nokuthintela ukubuyela kwakhona kosulelo lwe-C. difficile. Ababoneleli bezempilo badlala indima ebalulekileyo ekukhokeleni ukusetyenziswa ngokufanelekileyo kwe-fidaxomicin ukulawula i-CDI ngokufanelekileyo kunye nokukhuthaza ukubuyiselwa kwesigulana.