I-Fmoc-Arg(pbf)-OH CAS:154445-77-9

I-Fmoc-Arg(pbf)-OH isebenza umsebenzi obalulekileyo ekuqulunqweni kwe-peptide, ngakumbi kwiimeko ezifuna ukhuseleko olulawulwayo lwe-guanidine nitrogen kwi-arginine. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liququzelela iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-pbf kwi-guanidine nitrogen libonelela ngomaleko owongezelelweyo wokhuseleko. Abaphandi basebenzisa i-Fmoc-Arg(pbf)-OH ekuqulunqweni kwee-peptides ngotshintsho oluthile lwe-guanidine, nto leyo echaphazela imisebenzi yazo yebhayoloji. Icebo lokukhusela eliphindwe kabini lenza ukuba i-guanidine reactivity isebenze ngokuchanekileyo, nto leyo eyenza le compound ibe luncedo kuyilo nakuphuhliso lwee-peptides kwizifundo zokulwa ne-antimicrobial, i-bioconjugation, kunye ne-medical chemistry. Ukuhambelana kwe-Fmoc-Arg(pbf)-OH neendlela ezisemgangathweni zokwenziwa kwe-peptide, kubandakanya i-solid-phase peptide synthesis (SPPS), kuphucula ukusetyenziswa kwayo. Le compound ifumana ukusetyenziswa ekwakhiweni kwee-peptides kwiimvavanyo zebhayoloji, ukufunyanwa kwamayeza, kunye nophuhliso lwezinto ezisekwe kwi-peptide. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-arginine kunye ne-guanidine eguquliweyo, okufaka isandla kwiintlobo ngeentlobo zeepeptides ezinokwenziwa. Ngamafutshane, i-Fmoc-Arg(pbf)-OH imi njengesixhobo esikhethekileyo nesinokuguquguquka kwi-peptide chemistry, esinika amandla abaphandi ukuba baphonononge kwaye batshintshe i-guanidine reactivity kwiindidi ezahlukeneyo zezicelo zesayensi kunye nezonyango.