I-Fmoc-D-Gln-OH CAS:71989-20-3

I-Fmoc-D-Gln-OH isebenza njengesixhobo esikhethekileyo kwi-peptide synthesis, eyenzelwe ngokukodwa ukwenza iipeptides ezine-D-glutamine ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa ukufakwa kwe-D-enantiomer kongeza ubukhulu obukhethekileyo kwiipeptides ezihlanganisiweyo. Abaphandi basebenzisa kakhulu i-Fmoc-D-Gln-OH ekwenzeni iipeptides kwizicelo ezahlukeneyo, kubandakanya izifundo ezibandakanya ii-D-amino acids, unyango olusekelwe kwi-peptide, kunye neepeptides ezisebenzayo ezineemotifs ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kwe-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-D-glutamine kwizicwangciso ze-peptide, kwandisa amathuba okwenza iipeptides nge-stereochemistry eguquliweyo. Ngaphezu koko, i-Fmoc-D-Gln-OH ifumana uncedo kwizifundo ezinxulumene ne-peptidomimetics, apho ukusetyenziswa kwe-D-amino acids kunokunika uzinzo oluphuculweyo kunye nomsebenzi otshintshileyo kwi-peptides ezidityanisiweyo. Ukusetyenziswa okucwangcisiweyo kwe-Fmoc-D-Gln-OH kwenza ukuba i-D-glutamine reactivity isebenze ngokuchanekileyo, kunika abaphandi isixhobo esibalulekileyo sokuyila ii-peptides ezineempawu ezikhethekileyo ze-stereochemical. Ngamafutshane, i-Fmoc-D-Gln-OH imi njengesixhobo esikhethekileyo nesibalulekileyo kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-D-glutamine reactivity kwizicelo ezithile zesayensi, ngakumbi igxile kwii-peptides eziqulethe olu hlobo lwe-enantiomeric lwe-amino acid ebalulekileyo.