I-Fmoc-Tyr(But)-OSu CAS:155892-27-6

I-Fmoc-Tyr(But)-OSu isebenza njenge-reagent ebalulekileyo ekuhlanganisweni kwe-peptide, ngakumbi ekuguqulweni okukhethiweyo kweeproteni kunye nee-peptide. Ukusebenza kwe-OSu ester kuvumela ukuhlanganiswa okusebenzayo kwe-tyrosine kwiimolekyuli eziqulethe i-amine okanye iinkxaso eziqinileyo, okwenza kube lula ukungeniswa kweentsalela ze-tyrosine kwiindawo ezithile ngaphakathi kolandelelwano lwe-peptide. Iqela le-Fmoc linokususwa phantsi kweemeko ezibuthathaka ukuze kubonakale i-reactive OSu ester, okuvumela ukusabela okulandelayo kokudibanisa. Ngaphezu koko, i-Fmoc-Tyr(But)-OSu isetyenziswa kakhulu kwizicwangciso ze-bioconjugation zokuphuhlisa ii-conjugates zeproteni-amayeza, ii-probes zomfanekiso ezisekelwe kwi-peptide, kunye nezakhiwo ze-vaccine. Ukuhambelana kwayo nokuhlanganiswa kwe-peptide yesigaba esiqinileyo kwenza ukuba kudalwe ii-conjugates ze-peptide ezenzelwe ukusetyenziswa kwe-biomedical ezahlukeneyo, kubandakanya ukuhanjiswa kwamayeza ajoliswe kuwo kunye nezixhobo zokuxilonga. Ngamafutshane, i-Fmoc-Tyr(But)-OSu idlala indima ebalulekileyo ekuphuculeni uphando lwe-bioconjugation kunye ne-peptide chemistry, inika amandla izazinzulu kunye nabaphandi ukuba baphuhlise ii-conjugates kunye nee-peptide ezintsha ezinezicelo zonyango, zokuxilonga, kunye nophando.