I-Heparin sodium CAS:9041-08-1

Isiphumo ekuqhekekeni kwegazi: I-Heparin sodium isebenza ngokuthintela ukwakheka kwamahlwili egazi. Ibopha kwi-antithrombin, iproteni yendalo emzimbeni, kwaye iphucula amandla ayo okuthintela izinto ezibangela ukuqhekeka kwegazi, ngakumbi i-thrombin kunye ne-factor Xa. Oku kuthintela ukuguqulwa kwe-fibrinogen ibe yi-fibrin, ukwakheka kwe-thrombin, kunye nokwakheka kwamahlwili egazi okulandelayo.

Ukuthintela i-deep vein thrombosis (DVT) kunye ne-pulmonary embolism (PE): I-Heparin sodium isetyenziswa rhoqo ukuthintela ukwakheka kwamahlwili egazi kwimithambo (DVT) aze emva koko aye emiphungeni (PE). Idla ngokusetyenziswa njengonyango lokuthintela ngaphambi kotyando, ngexesha lokulaliswa esibhedlele, okanye kwizigulane ezisengozini enkulu yokwakheka kwamahlwili egazi.

Unyango lwezihlwili zegazi ezikhoyo: I-Heparin sodium ingasetyenziswa nangokwezonyango ukunyanga izihlwili zegazi ezikhoyo. Kwezi meko, inceda ekuthinteleni ukukhula kwezihlwili zegazi kwaye inciphise umngcipheko weengxaki, ezifana nestroke okanye ukuhlaselwa yintliziyo.

I-Hemodialysis kunye nokujikeleza kwegazi ngaphandle komzimba: I-Heparin sodium isetyenziswa ngexesha leenkqubo ze-hemodialysis kunye nokujikeleza kwegazi ngaphandle komzimba ukuthintela ukujiya kwegazi ngaphandle komzimba. Yongezwa kwi-dialysate okanye ijikeleziswe ngomatshini we-cardiopulmonary bypass ukuthintela ukujiya kwegazi ngaphakathi kwezi zixhobo.

Ukubeka esweni unyango lwe-anticoagulant: I-Heparin sodium ikwasetyenziselwa ukujonga ukusebenza kakuhle kwamanye amayeza e-anticoagulant, njenge-warfarin. Ixesha le-partial thromboplastin (PTT) okanye ixesha le-activated partial thromboplastin (aPTT) linokulinganiswa ukuqinisekisa amanqanaba onyango e-anticoagulant kunye nokulungisa umthamo ngokufanelekileyo.

Ukuthintela ukukhulelwa kunye neemeko ezithile zempilo: I-Heparin sodium inganikwa abafazi abakhulelweyo abasengozini enkulu yeengxaki zokunqamana kwegazi, ezifana ne-deep vein thrombosis okanye ukuphuphuma kwesisu okuphindaphindiweyo. Ikwasetyenziswa nakubantu abaneemeko ezithile zempilo, ezifana ne-antiphospholipid syndrome okanye ezinye iimeko zentliziyo, ukuthintela ukwakheka kwamahlwili egazi.