I-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) I-CAS:666832-71-9

Kwi-organic chemistry, i-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) isebenza njengebhloko yokwakha eguquguqukayo yokuhlanganisa ii-peptide chain ezinee-motifs ezithile eziqulethe i-valine. Iqela layo lokukhusela i-trifluoroacetyl linceda ukwakheka kunye nokuguqulwa kwe-peptide bond ekhethiweyo, okuvumela ukwenziwa okulungiselelweyo kwee-peptide analogs, ii-peptide conjugates, kunye nee-peptidomimetics. Abaphandi basebenzisa le compound ukuphonononga ubudlelwane bolwakhiwo-umsebenzi wee-peptides, ukuyila unyango olusekelwe kwi-peptide, kunye nokuphuhlisa ulandelelwano olutsha lwe-peptide oluneempawu zebhayoloji eziphuculweyo. Le compound ifumana usetyenziso ekuhlanganisweni kwe-peptide kunye nokufunyanwa kwamayeza, apho idlala indima ebalulekileyo ekudaleni iimolekyuli ze-peptide ezinemisebenzi eyahlukeneyo ye-pharmacological kunye nokusebenzisana okujoliswe kuko. I-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) ivumela ukufakwa kwee-valine residues kwizakhiwo ze-peptide ukuphucula uzinzo lwazo, ukufumaneka kwezinto eziphilayo, kunye nokubopha i-affinity kwi-biological receptors. Ukusetyenziswa kwayo ekuguqulweni nasekusebenzeni kwe-peptide kunceda ekuphuhlisweni kwamayeza e-peptide, izithinteli ze-enzyme, kunye neearhente zokuxilonga ezinokusetyenziswa kwi-biotechnology, amayeza, kunye nophando lwe-biomedical. Ngaphakathi kwishishini lamayeza, i-L-Valine, i-3-methyl-N-(trifluoroacetyl)- (9CI) isetyenziselwa ukwenziwa kwee-peptides eziqulethe i-valine, ii-peptidic prodrugs, kunye nee-nanoparticles ezisekelwe kwi-peptide ukuze kuhanjiswe amayeza. Indima yayo kwi-peptide chemistry kunye nobunjineli be-peptide ivumela uyilo lwee-scaffolds ezintsha ze-peptide ezineempawu zonyango eziphuculweyo kunye nokunciphisa ukuqina komzimba. Ngokusebenzisa iimpawu ezizodwa zale khompawundi, izazinzulu zinokuhlola iindlela ezintsha zophuhliso lwamayeza asekelwe kwi-peptide, amayeza enzelwe umntu ngamnye, kunye nonyango olujoliswe kwizifo ezahlukeneyo, kubandakanya umhlaza, izifo ezosulelayo, kunye neengxaki ze-metabolic.