I-Letrozole CAS: 112809-51-5 uMboneleli woMvelisi

I-Letrozole yinxalenye yesizukulwana esitsha se-aromatase inhibitors ekhethiweyo kakhulu kwaye i-artificially synthesized benzotriazole derivative.I-Letrozole inqanda i-aromatase ekunciphiseni amanqanaba e-estrogen, ngaloo ndlela ikhusela i-estrogen ekukhuthazeni ukukhula kwe-tumor.Umsebenzi wayo we-vivo unamandla ngamaxesha angama-150-250 kunalowo wesizukulwana sokuqala i-aromatase inhibitor i-Amarante.Njengoko ikhetha kakhulu, ayiyi kuchaphazela i-glucocorticoid, i-mineralocorticoid kunye nemisebenzi ye-thyroid;nakwiidosi eziphezulu, aziyi kuba nemiphumo yokuthintela kwi-adrenal corticosteroid secretion, inika isalathisi esiphezulu sonyango.

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I-Letrazole inokwenziwa ngamanyathelo amabini ukusuka kwi-4-bromomethyl-benzonitrile kunye ne-1,2,4-triazole kwaye isizukulwana sesithathu se-aromatase inhibitor.Yi-inhibitor ekhethekileyo ye-P450arom ethintela ukuguqulwa kwe-androstenedione kwi-estrone.Ukunciphisa i-estrogen ye-plasma kwakhawuleza kwaye kwahlala ixesha elide.Oku kufezekiswa ngaphandle kokuthintela enye i-steroid biosynthesis eyenza ukuba ibe yeyona inhibitor ekhethiweyo ye-aromatase evavanyiweyo.I-Letrazole inomsebenzi ophawulekayo we-antitumor, inyamezeleke kakuhle kwaye ayinayo imiphumo emibi yetyhefu.Ngamaxesha angama-10,000 anamandla ngakumbi kune-aminoglutethimide, kwi-vivo, i-aromatase inhibitor yokuqala esekwe kakuhle.

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Iinkcukacha ezongezelelweyo:

Ukuqamba	C17H11N5
Isivavanyi	99%
Imbonakalo	Umgubo omhlophe
Inombolo yeCAS.	112809-51-5
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.