I-N-Acetyl-L-phenylalanine ethyl ester CAS:2361-96-8

I-N-Acetyl-L-phenylalanine ethyl ester isetyenziswa kakhulu kwi-peptide chemistry kunye noyilo lwe-prodrug, isebenza njengendawo ebalulekileyo yokwenziwa kwee-peptides kunye ne-modified amino acid derivatives. Iingcali zekhemistri kunye nabaphandi basebenzisa le compound ukungenisa utshintsho oluthile okanye utshintsho lwesakhiwo kwi-peptide sequences, okuvumela ukuphuhliswa kwee-compounds ezintsha ze-bioactive kunye nee-agents zamayeza ezineempawu eziphuculweyo ze-pharmacokinetic kunye neempawu zokuhanjiswa ezijolise kuzo. Ngaphezu koko, i-N-Acetyl-L-phenylalanine ethyl ester isetyenziswa kuphuhliso lwee-prodrugs, apho ulwakhiwo lwayo lweekhemikhali kunye nozinzo lunegalelo ekuhlanganisweni kwee-agents zonyango ezinokubakho. Ngokubandakanya i-ethyl ester moiety, yenza kube lula ukwenziwa kwee-prodrugs ezine-lipophilicity ephuculweyo kunye ne-membrane permeability, iphucula ukufumaneka kwazo kunye nokuzinza kwe-metabolic ekunikezelweni kwamayeza ekujoliswe kuwo kunye nezicelo zokukhululwa ezilawulwayo. Ngaphezu koko, i-N-Acetyl-L-phenylalanine ethyl ester isetyenziswa kuphando lwamayeza ukuphanda ubudlelwane besakhiwo nomsebenzi, ukuphuhlisa abaviwa bamayeza amatsha, kunye nokuphonononga amaqhinga e-prodrug okuphucula iprofayili yonyango lwee-pharmaceuticals ezisekelwe kwi-phenylalanine. Indima yayo kuyilo kunye nokwenza ngcono iiprodrugs inegalelo ekuphuculeni ukufunyanwa kwamayeza kunye nophuhliso lwamayeza, inika ulwazi oluxabisekileyo malunga nokuphucula ukusebenza kakuhle kunye nokhuseleko lweearhente zonyango ezinokubakho. Ngamafutshane, i-N-Acetyl-L-phenylalanine ethyl ester idlala indima ebalulekileyo ekuphuculeni uphando lwesayensi, ukwenziwa kwepeptide, uphuhliso lweprodrug, kunye nezifundo zamayeza, inika izazinzulu kunye neengcali isixhobo esiguquguqukayo sokuhlola usetyenziso olwahlukeneyo lwee-phenylalanine derivatives ekufumaneni amayeza, uyilo lweprodrug, kunye nophando lwamayeza.