I-Acetyl Octapeptide-3 CAS: 868844-74-0 ukwakheka kunye nokusetyenziswa

I-Acetyl Octapeptide-3 (CAS 868844-74-0) yi-peptide yokwenziwa eyaziwayo kwisayensi yokuhombisa, edla ngokuthengiswa phantsi kwegama lorhwebo i-SNAP-8. Makhe sihlalutye indlela equlunqwe ngayo kunye nokusetyenziswa kwayo ngokweenkcukacha.

1. Ubuwena kunye nendlela yokusebenza

· Ukuchonga iikhemikhali:Yi-peptide eyenziwe nge-acetylated synthetic ene-sequence ye-Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2. I-acetylation iphucula ukungena kwayo kunye nokuqina kwesikhumba.

· Indlela Eyintloko:Idla ngokubizwa ngokuba “yindlela yeBotox yangaphandle,” isenzo sayo sisekelwe ekuthinteleni ukukhuphisana. Ilinganisa isiphelo se-N-terminal seprotheyini ye-SNAP-25, icandelo eliphambili kwi-SNARE complex efunekayo ekukhutshweni kwee-neurotransmitters (ezifana ne-acetylcholine) ezibonisa ukuxinana kwemisipha.

· Isiphumo esiPhambili:Ngokukhuphisana ne-SNAP-25 yendalo ukuze ifumane indawo kwi-SNARE complex, ithintela ukwakheka kwe-complex esebenza ngokupheleleyo. Oku kubangela ukuncipha okuncinci kokukhululwa kwe-neurotransmitter, okukhokelela ekunciphiseni ubukhali kunye nokuphindaphindeka kokucutheka kwemisipha yobuso obungaphezulu, ngaloo ndlela ithambisa ukubonakala kwemigca yokubonakalisa, ngakumbi ebunzini nakwamehlo.

2. Izikhokelo zoYilo

I-Acetyl Octapeptide-3 sisithako esinamandla kodwa esithambileyo. Ukwenziwa kwayo ngendlela efanelekileyo kubalulekile ukuze kubekho uzinzo nokusebenza kakuhle.

A) Ugxininiso olucetyiswayo:

· Inqanaba eliqhelekileyo lokusetyenziswa liphakathi2% ukuya kwi-10%yesisombululo se-peptide esixutyiweyo kwangaphambili.

· Umxholo we-peptide osebenzayo kwizinto eziluhlaza (ngokuqhelekileyo umgubo omhlophe ocoliweyo) udla ngokwenziwa ube semgangathweni. Ababoneleli abaqhelekileyo bezorhwebo bayinika njenge2% okanye 5%isisombululo esinyibilikisiweyo (emanzini okanye emanzini/umxube we-glycerin) ukuze kube lula ukuyila.

· Uxinzelelo lokugqibela lwe-peptide esebenzayo kwimveliso yokugqibela ludla ngokuqala kwi0.0005% ukuya kwi-0.002% (5-20 ppm)Landela rhoqo iingcebiso zedosi ethile zomthengisi wakho wezinto eziluhlaza.

B) Ukunyibilika kunye nesithuthi:

· Ayinyibiliki emanzini kakhulu. Yenziwe kakuhle xa imveliso ikwinqanaba lolwelo.

· Izithuthi ezifanelekileyo ziquka:

· Iiserum (ezixhaphakileyo)

· Iijeli

· Iikhrimu kunye neeLotions (kufuneka zifakwe kwisigaba samanzi ngaphambi kokuba zixutywe)

· Izithambiso eziphilisa amanzi

· Izisombululo Ezitshizwayo

C) i-pH kunye nozinzo:

· Uluhlu lwe-pH olufanelekileyo:5.0 – 7.0Ukwenziwa ngaphakathi kolu luhlu kuqinisekisa uzinzo lweekhemikhali kunye nokuhambelana kolusu.

· Ziphephe iindawo ezine-asidi eninzi (pH < 4) okanye i-alkaline (pH > 8) ixesha elide.

D) Ubushushu kunye nokuCwangciswa:

· Iyabuva ubushushu. Ukuthintela ukubola:

· Yongeza kwisigaba samanzi ngaphantsi okanye ngaphantsi40°C (104°F).

· Indawo efanelekileyo yokongeza kusemva kokuba i-emulsion ipholile ukuya ngaphantsi kwama-40°C, okanye uyinyibilikise emanzini obushushu begumbi ukuze ufumane ii-serum/ii-gel.

· Kuphephe ukucutshungulwa kobushushu obuphezulu njengokuzalisa okushushu ngaphandle kokuba idatha yozinzo iyakuqinisekisa oko.

E) Ukuhambelana kunye neZithako eziHlanganisiweyo:

· Ibalasele kakhulu kunye nezinye iipeptides ezilwa nokwaluphala (umz., iMatrixyl, iArgireline), i-hyaluronic acid, i-niacinamide, ii-antioxidants (iiVitamin C kunye ne-E), ii-moisturizers.

· Iintlanganisela ezisebenzisanayo:

· Nezinye iipeptides ze-neuromodulating: Zidla ngokudityaniswa ne-Acetyl Hexapeptide-8 (Argireline) ukuze kubekho isiphumo esibanzi nesithintelayo kwiithagethi ezininzi.

· Ngeepeptides ezikhulisa i-collagen: Ukudibanisa neepeptides ezifana nePalmitoyl Tripeptide-1 okanye iMatrixyl kujongana nemigca eguqukayo (evela kwintshukumo yemisipha) kunye nemigca engashukumiyo (evela ekulahlekelweni kwenkxaso yesakhiwo).

· Ziphephe: Izinto ezinamandla zokuxoza okanye zokunciphisa i-oxidation. Lumka ngeekhompawundi ezithile ze-ionic ezinokuchaphazela ukunyibilika okanye ukwakheka kwayo.

F) Ugcino:

· Njengesithako esinyibilikayo emanzini, umxube wokugqibela ufuna inkqubo yokugcina izinto ebanzi ukuze kuthintelwe ukukhula kweentsholongwane ezinokuthi zonakalise i-peptide.