I-Neocuproine reagent yi-reagent yokumisela ubhedu, ikristale emhlophe okanye emthubi-mdaka, iyacaphukisa. Isetyenziswa kakhulu njenge-reagent yokumisela i-cuprous, photometric determination ye-copper, ukumisela iswekile yegazi e-ultra-micro; i-organic synthesis. I-Neocuproine hydrochloride monohydrate isetyenzisiwe ekulinganiseni ukunyibilika kobhedu kwii-Cu-Ni alloys kusetyenziswa indlela ye-colorimetric. Ikwasetyenziswe ekulungiseleleni isisombululo se-complexing agent ekufundeni uvavanyo lwe-antioxidant capacity kwiisampulu zebhayoloji ezisekelwe kwi-Cu reducing complexes. Ingasetyenziswa njengomzekelo wokulungiselela i-neocuproine, isetyenziswa njenge-analytical reagent yokumisela ubhedu kwiisampulu zokusingqongileyo kusetyenziswa indlela ye-spectrophotometric.
Kodwa ke eli yeza lisetyenziswa ngeendlela ezahlukeneyo kwezonyango. Kutshanje, i-Eribulin ivunyiwe ukuba ithengiswe yi-National Medical Products Administration (NMPA) yelizwe lam ukuze inyange izigulane ezinomhlaza webele ezihlala ziphinda-phinda okanye ezihlala zisasazeka eziye zafumana ubuncinane iindlela ezimbini ze-chemotherapy (kuquka i-anthracyclines kunye ne-taxans) kwixesha elidlulileyo. Izise iphethini entsha yonyango kwicandelo le-chemotherapy yomhlaza webele eTshayina, Ikwazisa nezinye iindlela zonyango kwizigulane.
I-Eribulin yi-non-taxane tubulin inhibitor. Ngokungafaniyo ne-taxane kunye ne-vinblastine tubulin inhibitors, i-Eribulin inendlela ekhethekileyo yokusebenza, eyenza i-Eribulin isasebenza kwizigulana emva kokuchasana namayeza kwi-yew; i-Eribulin ikwanazo neziphumo ezingezizo ze-cytotoxic, kubandakanya ukuvuselelwa kwemithambo yegazi, ukwandisa ukusasazeka kwamanye amayeza kwindawo encinci ye-tumor, ukusebenzisana namanye amayeza, kunye nokuguqula iiseli ze-tumor Inguqu ye-epidermal-mesenchymal njalo njalo.
Ukususela ekuhlanganisweni ngokupheleleyo kwe-halichondrin B, ukusetyenziswa kwee-reagents ezintsha zobhedu njengezinto eziphakathi, ukuya kutshintsho lwesakhiwo se-Eribulin, ukuya kwimveliso yemizi-mveliso ye-Eribulin, izazinzulu ezivela kwi-academia nakwiinkampani zamayeza zichithe iminyaka engaphezu kwama-20 zihlola. Iimveliso zendalo ezivela elwandle ziye zaba ngamayeza anokunyanga umhlaza. Uphando nophuhliso lwe-Eribulin kungenxa yokuba i-reagent entsha yobhedu iyimfuneko njengeyona ndawo iphambili ye-API yayo. I-reagent entsha yobhedu inendima enkulu njenge-intermediate yamayeza kunye ne-reagent yokucoca izixhobo eziphezulu.
Ulwakhiwo lwemolekyuli ye-Eribulin luqulathe amaziko e-chiral ali-19, kwaye amanyathelo okwenziwa afikelela kumanyathelo angama-62. Ukuza kuthi ga ngoku, i-Eribulin isabonwa lishishini njengeyeza elingelona i-peptide eliyinkimbinkimbi eliveliswa yi-pure chemical synthesis, kwaye ingabizwa ngokuba yiMount Everest kwishishini lokwenziwa kweekhemikhali.
Uludwe oluphumeleleyo lwe-Eribulin lubonisa ukuphakama okutsha okunokufunyanwa ziinkampani zamayeza ekuvelisweni kweekhemikhali nakwimveliso yemizi-mveliso. Kukwazisa neengcinga ezingakumbi zokuxilonga kunye nonyango kunye neendlela zokukhetha koogqirha baseTshayina. Kuthenjwa ukuba kwixesha elizayo, iyeza elitsha le-chemotherapeutic i-Eribulin linokuzisa ithemba elitsha kwizigulane ezinomhlaza webele.
Ixesha lokuposa: Jan-01-2021