Uphononongo lwamva nje lweVitamin K2 MK7

I-Vitamin K2 MK7 (iMenaquinone-7) luhlobo olubalulekileyo nolusebenzayo lwe-Vitamin K2, olufumana ingqalelo enkulu ngenxa yendima yalo ebalulekileyo kwimpilo yentliziyo kunye namathambo. Nantsi inkcazelo eneenkcukacha.

· Ubunikazi beekhemikhali: I-Vitamin K2 yinxalenye yosapho lwe-menaquinone (MK), oluphawulwa luchungechunge olusecaleni lweeyunithi ze-prenyl eziphindaphindayo. I-MK7 ngokukodwa ineeyunithi ezi-7 ze-isoprenoid (“i-MK” imele i-Menaquinone, “7″ imele ubude bechungechunge).

· Imithombo yendalo:

· Ukutya Okubilisiweyo: Umthombo wokutya otyebileyo yi-natto (ukutya kwendabuko kwaseJapan okwenziwe ngeesoya ezibilisiweyo). Okunye ukutya okubilisiweyo okufana netshizi ezithile (umz., iGouda, iBrie) kunye ne-sauerkraut kuqulethe izixa ezincinci neziguquguqukayo.

· Imithombo Yezilwanyana: Ifumaneka ngomlinganiselo ophantsi kwiingqayi zamaqanda, isibindi, kunye nenyama enamafutha evela kwizilwanyana ezitya ingca.

· Izongezo: Zifumaneka ngokubanzi njengesongezelelo sokutya, ngokuqhelekileyo zifumaneka kwi-natto fermentation okanye zenziwe ngokwenziwa. Zidla ngokudityaniswa neVithamin D3 kunye necalcium ukuze kubekho iziphumo zokusebenzisana.

Le yingcamango ephambili eyahlula iVithamin K2 (ingakumbi iMK7):

· Ivuselela iMatrix Gla Protein (MGP): I-MGP sisithinteli esinamandla se-vascular calcification. Ibopha kwii-calcium ions ezindongeni zemithambo yegazi kwaye iwathintele ekungeneni kwizicubu ezithambileyo (imithambo yegazi, izintso). I-MK7 ivuselela i-MGP. Ngaphandle kwe-K2 eyaneleyo, i-MGP ayisebenzi, nto leyo eyonyusa umngcipheko wokuqina kwemithambo yegazi kunye nesifo sentliziyo.

· Ivuselela i-Osteocalcin: I-Osteocalcin yiproteni eveliswa yi-osteoblasts (iiseli ezakha amathambo). Umsebenzi wayo kukubopha i-calcium nokuyidibanisa kwi-bone matrix, iqinisa amathambo. I-MK7 ivuselela i-osteocalcin.

· Isifaniso "soMlawuli weKhalsiyam": Cinga ngeVithamin D "njengomgcini-sango" oqinisekisa ukuba icalcium eyaneleyo ifunxwa emathunjini iye egazini. IVithamin K2 (MK7) isebenza "njengomlawuli wethrafikhi" okanye "i-shuttle," iqinisekisa ukuba icalcium ifakwa emathanjeni (nge-osteocalcin) kwaye igcinwe ngaphandle kwemithambo yegazi (nge-MGP).

1. Impilo yeNtliziyo neMithambo yeNtliziyo:

· Yehlisa Ukuqina Kwemithambo kunye Nokwakheka Kwemithambo: Izifundo ezininzi zokujonga kunye nokungenelela zidibanisa ukutya okuphezulu kwe-K2 (MK7) kunye nomngcipheko ophantsi wesifo sentliziyo, ukwakheka kwemithambo yegazi, kunye nokufa. Uphononongo lweROTTERDAM luphononongo oludumileyo olubonisa le nzuzo.

· Iphucula ukutyeba: Ukongezwa (umz., 180-360 µg/ngosuku kangangeminyaka eliqela) kubonisiwe ukuba kuphucula ukuguquguquka kwemithambo yegazi.

2. Impilo Yamathambo:

· Inciphisa umngcipheko wokwaphuka kwamathambo: Ingakumbi abafazi abasele beyekile ukuya exesheni. I-K2 isebenza ngokubambisana neVithamin D kunye necalcium ukuphucula uxinano lwamathambo (BMD) kunye nokunciphisa ukwanda kwamathambo (umqolo kunye nesinqe).

· Ithintela i-Osteoporosis: Ngokusebenzisa ngokupheleleyo i-osteocalcin, ixhasa inkqubo yokuguqulwa kwamathambo, ikhuthaza ukwakheka kwamathambo endaweni yokufunxwa.

3. Ezinye izicelo ezinokubakho (Uphando oluvelayo):

· Uvelwano lwe-Insulin kunye neSifo seswekile: I-Osteocalcin, xa isebenza yi-K2, inokudlala indima ekuphuculeni uvakalelo lwe-insulin.

· Impilo Yezintso: Inokunceda ekuthinteleni ukuqiniswa kwemithambo yegazi kwizigulana ezinesifo sezintso esinganyangekiyo (CKD), nangona ukusetyenziswa kwi-CKD kufuna ulwalathiso lwezonyango ngenxa yeengxaki ezinokubakho.

· Impilo Yamazinyo: Njengethambo, inokuxhasa ukwenziwa kwamazinyo abe ngamaminerali nge-osteocalcin.

· Impilo Yokuqonda: Olunye uphando lokuqala ludibanisa impilo yemithambo yegazi (exhaswa yi-K2) nomngcipheko oncitshisiweyo wokuwohloka kwengqondo.

Faka iVithamin K2 MK7 Vitamin K2 MK4

Umthombo Ngokuyintloko uvela kwi-bacterial fermentation (natto). Ifumaneka kwimveliso yezilwanyana; uninzi lwezongezo zenziwe ngokwenziwa.

Ixesha Elifutshane Lobomi (~iiyure ezingama-72). Inika amanqanaba egazi azinzileyo nahlala ixesha elide ukusuka kwidosi enye. Imfutshane (~iiyure ezi-1-2). Ifuna idosi rhoqo (idla ngokuphindwe kaninzi ngemini).

Ukufumaneka kwe-Bioavailability Kuhle kakhulu; ixesha layo elide lokuphumla likhokelela kumanqanaba aphezulu nazinzileyo e-serum. Ukususwa kakuhle kodwa ngokukhawuleza kuthintela ukuqokelelana kwezicubu.

Idosi eqhelekileyo engama-90-360 µg/ngosuku iqhelekile xa kuncediswa. Isetyenziswa rhoqo kwiidosi ze-pharmacological (1.5-45 mg/ngosuku) kwizifundo zeklinikhi.

Ukusetyenziswa Okuphambili Impilo yokuthintela ixesha elide yamathambo kunye nemithambo yegazi (isongezo sokutya). Iyeza elinikwa ngugqirha (eJapan) lokuthintela i-osteoporosis kunye nokulahleka kwamathambo okubangelwa yi-steroid.

Ubungqina Idatha enamandla ye-epidemiological kunye neyovavanyo lweklinikhi olukhulayo lweenzuzo zentliziyo. Idatha enamandla yesilingo seklinikhi yeenzuzo zethambo kwiidosi eziphezulu ze-pharmacological.

Isiphelo: I-MK7 ikhethwa kakhulu xa isetyenziswa imihla ngemihla ngenxa ye-pharmacokinetics yayo ephezulu (isiqingatha sobomi obude), evumela ukuba idosi yenziwe kanye ngemini kwaye isebenze rhoqo kwiiproteni ezixhomekeke kwi-K.

· Idosi Eqhelekileyo Eyongeziweyo: Iqala kwi-90 micrograms (µg) ukuya kwi-360 µg ngosuku. Uninzi lwezifundo malunga neenzuzo zentliziyo zisebenzisa malunga ne-180-200 µg ngosuku.

· Ukhuseleko: Ikhuselekile kakhulu kwiidosi ezicetyiswayo kuluntu ngokubanzi. Akukho nqanaba letyhefu elaziwayo eliqinisekisiweyo.

· Ukusebenzisana Okubalulekileyo – Ii-Anticoagulants (iWarfarin/iCoumadin):

· IVithamini K iyayichasa impembelelo yeWarfarin. Izigulane ezisebenzisa iWarfarin kufuneka zigcine ukutya okuneVithamini K rhoqo (kwindlela yokutya kunye nezongezo) ukuze zigcine umthamo wazo wamayeza uzinzile.

· AKUBAFANELE baqalise okanye bayeke izongezo ze-K2 ngaphandle kokujonga ngokusondeleyo ugqirha kunye nokujonga rhoqo i-INR. Ii-anticoagulants ezintsha (ii-DOAC ezifana ne-apixaban, i-rivaroxaban) azisebenzisani neVitamin K.

· Ukusebenzisana: Soloko usela kunye neVithamin D3. Zizizibini ezinamandla zokusebenzisana. ICalcium kunye neMagnesium nazo zizinto ezibalulekileyo kwizakhamzimba.

· Uhlobo: Ii-softgels okanye ii-capsules ezine-oil-based carrier (umz., i-olive oil, i-MCT oil) zilungile, njengoko iVithamin K2 inyibilika ngamafutha.

· Iifomyula eziDibeneyo: Khangela iimveliso ezidibanisa i-K2 (MK7) + D3. Ukongeza inani elincinci leVithamin K1 kunokuba luncedo kwi-K-status epheleleyo.

· Umgangatho: Khetha iimpawu ezisebenzisa i-MK7 eguquguqukayo ngokupheleleyo (uhlobo olusebenzayo; ezinye iimveliso zokwenziwa zinokuba ne-isomer ye-cis engasebenzi kangako).

· Indawo yokugcina: Gcina kwindawo epholileyo nemnyama. Ihlala iqinile kwizithako zokondla ukuba ikhuselekile ekukhanyeni nasebushushwini.

Ngamafutshane, iVithamini K2 MK7 sisondlo esibalulekileyo esikhokelela icalcium kumathambo ngelixa sikhusela imithambo yegazi kunye nezicubu ezithambileyo kwi-calcium. Ubomi bayo obude obufutshane kunye nobungqina obuqinileyo buyenza ibe yinxalenye ebalulekileyo yenkqubo yokuthintela impilo, ngakumbi kwimpilo yentliziyo kunye namathambo, xa isetyenziswa kunye neVithamini D3.