I-PhentolamineMesylate CAS:65-28-1

I-Phentolamine mesylate isebenza indima ebalulekileyo kwiindlela zonyango kunye nophando. Njenge-vasodilator enamandla kunye ne-arhente yokulwa noxinzelelo lwegazi, isetyenziswa kunyango lweengxamiseko ze-hypertension, ngakumbi kwiimeko zengxaki ye-pheochromocytoma, apho ukunciphisa uxinzelelo lwegazi ngokukhawuleza kubalulekile. Ikwaluncedo ekulawuleni iziqephu ze-hypertension ezibangelwa yi-iatrogenic catecholamine ngexesha leenkqubo zotyando kunye nezinye iindlela zonyango. Kwizonyango zamazinyo, i-phentolamine mesylate isetyenziswa njenge-arhente yokuguqula i-anesthetic yendawo, inceda ekulawuleni i-anesthesia yezicubu ezithambileyo emva kweenkqubo zamazinyo ezibandakanya i-anesthetic yendawo equlethe i-vasoconstrictor efana ne-epinephrine. Iziphumo zayo ze-vasodilating zinceda ekunciphiseni ukunqongophala kwegazi lendawo kunye nokukhawulezisa ukubuyiselwa kokuphuma kwegazi okuqhelekileyo kwezicubu. Ngaphezu koko, le khompawundi isetyenziswa kwiinkqubo zokuxilonga ezifana nokuthintela kunye nokunyanga i-dermal necrosis ebangelwa kukukhupha amayeza asebenzayo, ukuqinisekisa ukuhanjiswa kwegazi ngokufanelekileyo kwezicubu. Ukongeza, ibandakanyeka kwizifundo zophando kunye novavanyo lweklinikhi oluhlola ukusetyenziswa kwayo okunokwenzeka kwiimeko ezinxulumene nokungasebenzi kakuhle kwemithambo yegazi, ukungasebenzi kakuhle kwe-erectile, kunye ne-Raynaud's phenomenon, enegalelo ekuphuhliseni unyango lwentliziyo kunye nomchamo. Indima ye-phentolamine mesylate ifikelela kwiindawo zovavanyo njengesixhobo kuphando lwezonyango kunye ne-physiological, inceda kuphando lomsebenzi we-adrenergic receptor, iimpendulo zemithambo yegazi, kunye nokuguqulwa komsebenzi wenkqubo ye-sympathetic nervous. Amandla ayo okuthintela ii-adrenergic receptors kunye nefuthe kwi-vascular tone anegalelo ekuqondeni i-physiology yentliziyo kunye nophuhliso lokungenelela konyango olujolise kwiindlela zokubonisa i-adrenergic. Ngokubanzi, ukusetyenziswa okuhlukeneyo kwe-phentolamine mesylate kugxininisa ukubaluleka kwayo kunyango lwezonyango, ugqirha wamazinyo, uphando, kunye nophuhliso lwamayeza, kugxininisa amandla ayo okufaka isandla kulawulo olusebenzayo lweemeko zentliziyo kunye nokuqhubela phambili ulwazi lwesayensi olunxulumene nomsebenzi we-adrenergic receptor kunye nokulawulwa kwemithambo yegazi.