I-Protein Kinase Supplement KT5823 CAS:126643-37-6 Umfanekiso obonisiweyo

Isongezelelo seProtein Kinase KT5823 CAS:126643-37-6

Isongezelelo seProtein kinase i-KT5823 sisithinteli semolekyuli esincinci esijolise ngokukodwa kwaye sithintele umsebenzi weProtein kinase. IiProtein kinases ziienzymes ezifosforasila iiproteni ngokongeza amaqela e-phosphate kwii-amino acid residues ezithile, ngesiqhelo i-serine, i-threonine, okanye i-tyrosine. Le nkqubo yefosforasila idlala indima ebalulekileyo kwiindlela ezahlukeneyo zokubonisana kweeseli, ukulawula ukusebenza kweproteni, kunye nokulawula iinkqubo zeseli ezifana nokukhula kweeseli, ukwahlukana, ukwahlukana, kunye ne-apoptosis.

I-KT5823 isetyenziswa rhoqo kwizifundo zophando ukuphanda umsebenzi kunye neendlela zokubonisa iimpawu zeeproteni kinases. Ngokuthintela iiproteni kinases, i-KT5823 inokunceda abaphandi ukuba bachonge iiproteni ezithile kunye neendlela ezichaphazeleka ngumsebenzi we-kinase. Olu lwazi lunokuba luncedo ekuqondeni indima yeeproteni kinases kwimisebenzi yeselula kunye nokuchonga iinjongo ezintsha zonyango.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

Isongezelelo seProtein kinase i-KT5823 sisithinteli esisetyenziswa kakhulu seProtein kinase G (PKG), esijolise ngokukodwa kuhlobo lwe-I isoform PKG-1. I-PKG yi-serine/threonine kinase edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zeseli ezifana nokuphumla kwemisipha egudileyo, ukuhlanganiswa kweeplatelet, kunye nokulawula i-vasodilation.

Isiphumo esiphambili se-KT5823 kukuthintela umsebenzi we-PKG-1 ngokukhuphisana ne-ATP ebopha kwi-kinase domain. Ngokuthintela i-PKG-1, i-KT5823 inokuphazamisa iindlela zokubonisa ezisezantsi kwe-activation ye-PKG-1, kuquka ii-cascade zokubonisa ezixhomekeke kwi-cGMP.

Ukusetyenziswa kwe-KT5823 ikakhulu kukwizifundo zophando ukuphanda umsebenzi kunye neendlela zokubonisa ze-PKG-1. Ukusetyenziswa kwayo ekuthinteleni umsebenzi we-PKG-1 kuvumela abaphandi ukuba bahlole iindima ze-PKG-1 kwiinkqubo ezahlukeneyo ze-physiological kunye ne-pathological. Ezinye zezicelo ezithile ze-KT5823 ziquka:

Ukuphanda ngokuphumla kwemisipha egudileyo: I-PKG-1 idlala indima ebalulekileyo ekuphumleni kwemisipha egudileyo. Ngokuthintela i-PKG-1 kusetyenziswa i-KT5823, abaphandi banokufunda iindlela ezisisiseko kunye neendlela ezibandakanyekayo ekuphumleni kwemisipha egudileyo, nto leyo ibalulekileyo kwiinkalo ezifana nophando lwentliziyo.

Ukufunda ngokuhlanganisa iiplatelet: I-PKG-1 ikwalawula ukuhlanganiswa kweeplatelet kunye nokwakheka kwamahlwili. Ukuthintela i-PKG-1 nge-KT5823 kuvumela abaphandi ukuba bavavanye impembelelo yomsebenzi we-PKG-1 kumsebenzi weeplatelet kwaye baqonde iindlela ezibandakanyekayo.

Ukuphonononga iithagethi ezisezantsi ze-PKG-1: Ngokuthintela i-PKG-1, abaphandi banokuchonga kwaye bafunde iithagethi ezisezantsi kunye neziphumo ze-PKG-1 signaling, bebonelela ngengqiqo kwiindlela ze-molecular ezisisiseko seempendulo zeselula ezilawulwa yi-PKG-1.

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	C29H25N3O5
Uvavanyo	99%
Inkangeleko	Umgubo omhlophe
Inombolo ye-CAS	126643-37-6
Ukupakisha	Encinci kwaye ininzi
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.