I-Reductase, i-glutathione CAS:9001-48-3

I-Glutathione reductase yi-enzyme edlala indima ebalulekileyo ekugcineni ibhalansi ye-glutathione encitshisiweyo neyi-oxidized (GSH/GSSG) kwiiseli. I-Glutathione yi-tripeptide eyenziwe yi-amino acids i-glycine, i-cysteine, kunye ne-glutamate. Isebenza njenge-antioxidant ephambili kwiiseli kwaye ibandakanyeka kwiinkqubo ezahlukeneyo zeeseli, kubandakanya ukususwa kweekhemikhali emzimbeni, ukwenziwa nokulungiswa kwe-DNA, kunye nokuveliswa kweproteni.

I-Glutathione reductase ikhuthaza ukunciphisa i-glutathione e-oxidized (GSSG) ukuya kwimo yayo enciphileyo (GSH) ngokusebenzisa i-NADPH (nicotinamide adenine dinucleotide phosphate) njenge-cofactor. Le mpendulo ibalulekile ekugcineni imeko enciphileyo ye-glutathione kwiiseli, njengoko i-GSSG inokuqokelelana xa kukho uxinzelelo lwe-oxidative.

Ngokugcina umlinganiselo ofanelekileyo we-GSH kwi-GSSG, i-glutathione reductase inceda ukukhusela iiseli kumonakalo we-oxidative obangelwa ziintlobo ze-oxygen (ROS) kunye nezinye iimolekyuli eziyingozi. Isebenza njengomdlali ophambili kwinkqubo yokukhusela iiseli nge-antioxidant.

Ngaphezu koko, i-glutathione reductase ikwabandakanyeka ekusetyenzisweni kwakhona kwe-glutathione disulfide (GSSG) eveliswa ngexesha leenkqubo ezahlukeneyo ze-metabolic, ukuqinisekisa ukuba ikhona i-glutathione encitshisiweyo (GSH) kwimisebenzi yayo emininzi yeseli.

Oda okanye Cela iKoteshini

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kunye nesiphumo

Ulawulo lweRedox: I-Glutathione reductase idlala indima ebalulekileyo ekugcineni ibhalansi ye-redox yeselula. Inceda ukugcina umlinganiselo ofanelekileyo we-glutathione encitshisiweyo (GSH) kwi-glutathione exoxisiweyo (GSSG) ngokuguqula i-GSSG ibuyele kwi-GSH. Le balance ye-redox ibalulekile kwiinkqubo ezininzi zeseli kwaye ibalulekile ekusindeni nasekusebenzeni kweseli.

Ukhuselo lwe-Antioxidant: I-Glutathione reductase, ngokugcina amanqanaba e-glutathione ancitshisiweyo, iphucula indlela yokukhusela i-antioxidant yeseli. I-Glutathione isebenza njenge-antioxidant enamandla, isusa iintlobo ze-oxygen ezisabelayo (i-ROS) kunye nezinye ii-free radicals eziyingozi ezinokubangela umonakalo weseli kunye noxinzelelo lwe-oxidative.

Ukususa ityhefu emzimbeni: I-Glutathione reductase ibandakanyeka ekususeni ityhefu kwiikhompawundi eziyingozi kunye ne-xenobiotics. Inceda ekuhlanganiseni izinto ezinobungozi kunye ne-glutathione, nto leyo ekhokelela ekususweni kwazo emzimbeni.

Umsebenzi wenkqubo yomzimba yokuzikhusela: I-Glutathione reductase idlala indima ebalulekileyo ekusebenzeni kwenkqubo yomzimba yokuzikhusela. Inceda ukugcina imeko ye-redox yeeseli zomzimba, ivuselela iimpendulo zomzimba ngokugqibeleleyo, kwaye ixhasa ukwanda nokwahluka kweeseli zomzimba.

Uphawu lokuxilonga kunye nokuxela kwangaphambili: Umsebenzi we-Glutathione reductase unokulinganiswa ukuvavanya imeko ye-redox kunye namanqanaba oxinzelelo lwe-oxidative kwizifo ezahlukeneyo. Utshintsho kumsebenzi we-glutathione reductase lunokusebenza njengophawu lokuxilonga kunye nokuxela kwangaphambili kwiimeko ezahlukeneyo, kubandakanya umhlaza, izifo zentliziyo, izifo zesibindi, kunye neengxaki ze-neurodegenerative.

Ukusetyenziswa kwezonyango: I-Glutathione reductase yeyona nto iphambili ekusetyenzisweni kwayo. Ukulawula ukusebenza okanye ukubonakaliswa kwayo kunokujongwa njengecebo lokunyanga izifo ezinxulumene noxinzelelo lwe-oxidative, ezifana neengxaki ze-neurodegenerative, izifo zentliziyo, kunye nomhlaza othile.

Ukupakisha imveliso:

Iinkcukacha ezongezelelweyo:

Ukwakhiwa	N / A
Uvavanyo	99%
Inkangeleko	Ulwelo oluphuzi
Inombolo ye-CAS	9001-48-3
Ukupakisha	Encinci kwaye ininzi
Beka ubomi kwishelufa	iminyaka eyi-2
Indawo yokugcina izinto	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	I-ISO.