I-S)-(+)-Camptothecin CAS:7689-03-4

(S) -(+)-I-Camptothecin ithembisa ekunyangeni iintlobo ngeentlobo zomhlaza, ingakumbi kwicandelo le-chemotherapy. Indlela esebenza ngayo ibandakanya ukujolisa nokuthintela umsebenzi we-topoisomerase I, i-enzyme ebalulekileyo ekukhululeni i-DNA ngexesha lokuhlukana kweeseli. Ngokuphazamisa le nkqubo, i-(S)-(+)-I-Camptothecin ithintela iiseli zomhlaza ekubeni ziphindaphindeke kwaye zande, ekugqibeleni ibangele i-apoptosis okanye ukufa kweeseli okucwangcisiweyo. Le khompawundi ibonakalise ukusebenza kakuhle ngokuchasene neentlobo ezahlukeneyo zomhlaza, kubandakanya umhlaza we-colorectal, i-ovarian, kunye nomhlaza wemiphunga weeseli ezincinci, phakathi kwezinye. Imizamo yophando igxile ekuphuhliseni ii-derivatives kunye neefomyula ze-(S)-(+)-I-Camptothecin ukuphucula ukunyibilika kwayo kunye nokufumaneka kwayo, ukuphucula ukusetyenziswa kwayo kwezonyango. Izifundo zeklinikhi kunye novavanyo zihlolisise ukusetyenziswa kwe-(S)-(+)-I-Camptothecin njenge-arhente enye okanye xa idityaniswa nezinye ii-arhente ze-chemotherapy ukuze kuphuculwe iziphumo zayo zokulwa nomhlaza ngelixa kunciphisa iimpendulo ezimbi. Nangona kunjalo, kubalulekile ukuqaphela ukuba i-(S)-(+)-Camptothecin inokubonakalisa ubuthi kunye nemiphumo emibi, nto leyo efuna ukujongwa nokulawulwa ngononophelo ziingcali zonyango. Ukuhlolwa kwe-(S)-(+)-Camptothecin kunye neziphumo zayo kuyaqhubeka nokuqhubela phambili kunyango lomhlaza, kunika ithemba leziphumo zonyango eziphuculweyo kunye nomgangatho wobomi kwizigulana ezilwa nezifo ezahlukeneyo zomhlaza.