(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine CAS:132335-44-5

Ukwenziwa kunye nokufundwa kwe-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine kufumene umdla kwiindawo zophando lwamayeza kunye neekhemikhali. Ukwenziwa kwe-enantioselective yale compound kuyinselele kodwa kubalulekile ukufikelela kwi-enantiomers ezicocekileyo zokufunda imisebenzi yazo yezonyango. Abaphandi baye baphuhlisa iindlela ezahlukeneyo zokwenziwa besebenzisa ii-chiral resolving agents okanye ii-catalysts ezingafaniyo ukuze bafumane i-enantiomer efunekayo. Izifundo zibonise ukuba i-(S)-enantiomer yee-beta-blockers ezifana ne-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine inokubonisa ukunamathela okuphezulu kunye nokukhetha kwii-receptors ze-beta-adrenergic xa kuthelekiswa ne-(R)-enantiomer, nto leyo eyenza ukuba ibe ngumviwa othembisayo wophuhliso oluthe kratya lwamayeza. Uphando olongezelelweyo malunga neempawu ze-pharmacological kunye nokukwazi ukunyanga kwe-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine kufanelekile ukuphonononga ukusebenza kwayo kunye neprofayili yokhuseleko kwiimeko zeklinikhi. Ukuqonda ubudlelwane bolwakhiwo nomsebenzi wale khompawundi kunye nokusebenzisana kwayo nee-beta receptors kunokukhokelela ekuphuhlisweni kwee-beta-blockers ezintsha ezineziphumo zonyango eziphuculweyo kunye neziphumo ebezingalindelekanga ezinciphileyo. Ngokubanzi, i-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine imele ikhemikhali exabisekileyo kwicandelo lophando lwamayeza, enika ulwazi malunga noyilo kunye nophuhliso lwamayeza entliziyo aneempawu ze-pharmacological eziphuculweyo.