I-Setmelanotide CAS:920014-72-8 uMboneleli woMvelisi

I-Setmelanotide yi-agonist ye-melanocortin-4 receptor (MC4R).Izicelo zayo ziquka ukunyangwa kwezifo ezithile zofuzo ezinxulumene nokutyeba, ezifana nokusilela kwe-pro-opiomelanocortin (POMC), i-leptin receptor (LEPR) kunye ne-Bardet-Biedl syndrome.I-Setmelanotide isetyenziselwa ukulawula ukukhuluphala kakhulu kwizigulane ezineemeko ezithile zofuzo, ngokunceda ukulawula ukutya kunye nobunzima bomzimba.Iimpembelelo eziqhelekileyo eziqhelekileyo ziquka ukuphendulwa kwendawo yokutofa, i-hyperpigmentation yesikhumba (iindawo zesikhumba ezimnyama kunesikhumba esijikelezileyo), intloko ebuhlungu kunye nesisu esiswini. iziphumo ezibi (ezifana ne-nausea, isifo sohudo, kunye neentlungu zesisu), phakathi kwabanye.Ukulungiswa kwe-penile okuzenzekelayo kumadoda kunye neempembelelo zesondo ezingathandekiyo kubasetyhini zenzeke ngonyango.Ukudandatheka kunye neengcamango zokuzibulala nazo zenzeke nge-setmelanotide.