I-Tetrabenzyl Dapagliflozin CAS:2001088-28-2

I-tetrabenzyl dapagliflozin, eyenziwe ngeendlela ezikhethekileyo ze-organic, inesakhiwo esintsonkothileyo se-molecular esibalulekileyo kwizicelo zayo ezahlukeneyo. Ukubakho kwezinto ezine ezithatha indawo ye-benzyl kwisiseko se-dapagliflozin kunefuthe kwindlela esebenza ngayo iikhemikhali, ukunyibilika, kunye nokusebenzisana neenkqubo zebhayoloji. Ezi mpawu zesakhiwo zibalulekile ekuqondeni iprofayili yayo ye-pharmacological kunye namandla okunyanga. Ukusetyenziswa kwiMichiza Le khompawundi inesithembiso kuphando lweyeza ngenxa yokwakheka kwayo. I-Dapagliflozin derivatives, eyaziwa ngendima yayo njenge-sodium-glucose co-transporter 2 (SGLT2) inhibitors, isetyenziswa kunyango lwesifo seswekile sohlobo lwesibini. Ukutshintshwa kwe-benzyl kwi-tetrabenzyl dapagliflozin kunokutshintsha iipropati zayo ze-pharmacokinetic okanye kuphucule ukukhetha kwayo kunye nokusebenza kwayo njenge-SGLT2 inhibitor. Umsebenzi weBiological kunye neendlela Izifundo zibonisa ukuba i-dapagliflozin kunye ne-derivatives zayo zisebenza ngeziphumo zazo zonyango ngokuthintela i-SGLT2 kwi-renal proximal tubules, ngaloo ndlela kunciphisa ukufunxwa kwakhona kwe-glucose kwi-renal kunye nokwandisa ukukhutshwa kwe-glucose kumchamo. Amaqela e-benzyl kwi-tetrabenzyl dapagliflozin anokuchaphazela amandla ayo, uzinzo lwe-metabolic, okanye ukusebenzisana nee-receptors ezingajoliswanga, nto leyo echaphazela iprofayili yayo iyonke ye-pharmacological. Iindlela zokwenziwa kunye nophuhliso Ukwenziwa kwe-tetrabenzyl dapagliflozin kubandakanya iinkqubo ezintsonkothileyo ze-organic eziqala kwi-dapagliflozin kunye ne-benzyl halides okanye i-benzyl alcohols. Ukuphucula iindlela zokwenziwa kubalulekile ekufezekiseni ubunyulu obuphezulu kunye nemveliso, ebalulekileyo kwizicelo zamayeza. Ngaphezu koko, ukucoca iindlela zokwenziwa kuphucula ukuguquguquka, ukusebenza kakuhle kweendleko, kunye nokuzinza ekuvelisweni kwamayeza. Uphando lwangoku kunye neMigqaliselo yexesha elizayo Imizamo yophando lwangoku igxile ekuphononongeni amandla e-tetrabenzyl dapagliflozin ngaphaya konyango lwesifo seswekile, kubandakanya ukusetyenziswa kwayo kwizifo zentliziyo okanye iingxaki ze-metabolic. Izifundo zexesha elizayo zinokuphanda utshintsho kwisakhiwo sayo ukuphucula ukufumaneka kwezinto eziphilayo, ukunciphisa iziphumo ebezingalindelekanga, okanye ukujolisa iindlela ezongezelelweyo zonyango. Uvavanyo lweklinikhi kunye nezifundo zangaphambi kweklinikhi ziyaqhubeka ukuvavanya ukhuseleko lwayo, ukusebenza kakuhle, kunye neziphumo zexesha elide. Isiphelo Ukuqukumbela, i-tetrabenzyl dapagliflozin imele ikhompawundi ephawulekayo kwikhemistri yamayeza kunye nophando lwamayeza ngenxa yesakhiwo sayo esahlukileyo seekhemikhali kunye nezicelo zonyango ezinokubakho. Ukufakwa kwamaqela amane e-benzyl kwisakhelo se-dapagliflozin kubonisa ukuguquguquka kwayo kunye nethemba lezonyango, ngakumbi kwizifo ezifana ne-type 2 diabetes mellitus. Ukuqhubela phambili uphando malunga neempawu zayo zamakhemikhali, ukusebenzisana kwezinto eziphilayo, kunye neendlela zokwenziwa kubalulekile ekwandiseni amandla ayo okunyanga kunye nokwandisa ukusetyenziswa kwayo kunyango lwezonyango.