I-Tritylcandesartancilexetil CAS:170791-09-0

I-Tritylcandesartan cilexetil, eyaziwa ngokuba yi-tritylcandesartan cilexetil, liyeza leyeza elisetyenziselwa kakhulu unyango lwe-hypertension (uxinzelelo lwegazi oluphezulu). Likudidi lwamayeza aziwa ngokuba yi-angiotensin II receptor blockers (ARBs). La mayeza asebenza ngokuthintela isenzo se-angiotensin II, into esemzimbeni enokubangela ukuba imithambo yegazi inciphe, ngaloo ndlela inyuse uxinzelelo lwegazi. Ngokuthintela le ndlela, i-tritylcandesartan cilexetil inceda ukuphumla nokwandisa imithambo yegazi, okukhokelela ekwehleni kwamanqanaba oxinzelelo lwegazi. Ukongeza kwindima yayo ekulawuleni uxinzelelo lwegazi, i-tritylcandesartan cilexetil inokunikwa ukukhusela izintso ekonakaleni ngenxa yesifo seswekile, ngakumbi kwizigulana ezinesifo seswekile sohlobo lwesibini kunye noxinzelelo lwegazi oluphezulu. Eli yeza libonakalisiwe ukuba linciphisa umngcipheko wokuqhubela phambili kwesifo sezintso kwaba bantu, okwenza ukuba libe lukhetho oluxabisekileyo kwizigulana ezinjalo. Ngaphezu koko, i-tritylcandesartan cilexetil inokuba yinxalenye yesicwangciso sonyango esibanzi sokusilela kwentliziyo. Inganikwa ukuze kuphuculwe iimpawu, kuncitshiswe ukulaliswa esibhedlele okunxulumene nokusilela kwentliziyo, kwaye kuphuculwe umgangatho wobomi kubantu abaphila nale meko. Kubalulekile ukuqaphela ukuba ukusetyenziswa kwe-tritylcandesartan cilexetil kufuneka kumiselwe yingcali yezempilo, kwaye izigulana kufuneka zilandele ngokungqongqo idosi emiselweyo kunye nemiyalelo yokusetyenziswa enikezelwa ngumniki-nkonzo wezempilo. Ukongeza, iziphumo ebezingalindelekanga ezinokubakho kunye nokusebenzisana namayeza kufuneka kuqwalaselwe ngononophelo xa kusetyenziswa eli yeza. Izigulana ziyacetyiswa ukuba zibonane nomboneleli wazo wezempilo ukuze zifumane isikhokelo esikhethekileyo malunga nokusetyenziswa kwe-tritylcandesartan cilexetil.