Ityuwa ye-trisodium ye-Uridine-5′-diphosphoglucuronic acid CAS:63700-19-6

Ukususa ityhefu emzimbeni: I-UDP-glucuronic acid yimolekyuli ebalulekileyo ebandakanyeka kwi-phase II biotransformation reactions ye-xenobiotics kunye nee-endogenous compounds. Isebenza njengomanduleli wokwenziwa kwe-glucuronides, ezizi-conjugates ezinyibilikayo emanzini ezinokususwa ngokulula emzimbeni. Le nkqubo yokususa ityhefu emzimbeni inceda ekupheliseni nasekususeni izinto ezinokuba yingozi, ezinje ngamayeza, iityhefu ezikwindalo, kunye nezinye izinto ezibangela i-metabolic.

Umetabolism yamayeza: Amayeza amaninzi afumana i-glucuronidation, inkqubo apho i-UDP-glucuronic acid idibana nemolekyuli yamayeza, nto leyo ebangela ukwakheka kwe-metabolite ye-glucuronide. Le mpendulo ye-glucuronidation idla ngokuphucula ukususwa kwamayeza emzimbeni kwaye iququzelele ukukhutshwa kwawo ngomchamo okanye inyongo. Ityuwa ye-UDP-glucuronic acid trisodium isetyenziswa rhoqo kwizifundo eziphanda imetabolism kunye ne-pharmacokinetics yamayeza.

Isixhobo sophando: Ityuwa ye-trisodium ye-UDP-glucuronic acid isetyenziswa kakhulu njengesixhobo sophando kwizifundo ezahlukeneyo ezinxulumene ne-metabolism yamayeza, i-enzymology, kunye ne-toxicology. Ibonelela ngomthombo we-UDP-glucuronic acid kwiimvavanyo ze-in vitro kwaye ivumela abaphandi ukuba baphande impembelelo ye-glucuronidation ekususweni kwamayeza, ukufumaneka kwawo emzimbeni, kunye nokusebenzisana okunokwenzeka phakathi kwamayeza namayeza.

I-Glycosylation: I-UDP-glucuronic acid ikwabandakanyeka kwiimpendulo ze-glycosylation, apho isebenza njengomnikeli we-glucuronic acid moieties ukuze kuhlanganiswe i-glycosaminoglycans (GAGs) kunye ne-proteoglycans. Ezi molekyuli zinendima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya ukunamathela kweseli, ukwakheka kwe-extracellular matrix, kunye nokubonisana.